爱维治对急性放射性肠炎大鼠肠道修复作用的实验研究  

Actovegin restores the digestive tract in rats with acute radiation enteritis

作　　者：毕迎惠[1] 韩俊庆[1] 盛巍[1] 李兆沛[1] 胡平平[1] 沈斌[1] 

机构地区：[1]山东大学山东省立医院肿瘤研究治疗中心,山东济南250021

出　　处：《山东大学学报（医学版）》2007年第3期274-278,共5页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨爱维治对急性放射性肠炎大鼠肠道的修复作用。方法:随机将Wistar大鼠28只分为正常对照组、爱维治组、模型对照组。建立辐射损伤模型(一次性用直线加速器给予9.0 Gy的高能X射线照射)。造模后连续4 d腹腔注射给药,取相应部位的空肠、回肠、结肠,光学显微镜下观察及图像分析仪测定其相关的形态学指标,并测定肠粘膜NO水平及细菌移位率。结果:爱维治组空肠、回肠和结肠粘膜基本完整,而模型对照组出现粘膜坏死、脱落;爱维治组空肠、回肠绒毛高度、隐窝深度、粘膜厚度和全层厚度及结肠粘膜和全层厚度均显著大于模型对照组。爱维治组肠粘膜NO浓度和细菌移位率显著低于模型对照组。结论:爱维治能加速急性放射性肠炎受损肠道粘膜的修复,抑制NO产生,对维持肠道粘膜结构和功能的稳定性有良好的作用。Objective： To evaluate the effect of Actovegin in restoring the digestive tract in rats with acute radiation enteritis. Methods： Whole abdominal radiation was performed on Wistar rats. The rats were randomly divided into three groups： the Actovegin group （Actovegin injection）, the control group（ irradiation only）, and the normal group （without irradiation）. Morphologic indices were measured by using light microscopy and the image analysis system. Intestinal NO concentration was detected by nitric acid reductase and bacterial translocation was also examined. Results： The Actovegin group had a significantly higher level of the height of the villus, the depth of crypt, the thickness of the mucosa and the entire wall, the number of the metaphase mitoses per crypt, and a significantly lower level of bacterial translocation and NO concentration compared with the control group. Conclusion： Actovegin accelerates recovery of injured digestive mucosal epithelium and decreases intestinal NO concentration and is good for regaining normal structure and function of digestive mucosa.

关 键 词：肠粘膜 辐射损伤 幼牛血清 

分 类 号：R459.3[医药卫生—治疗学]