心力衰竭患者血浆N末端脑钠素前体浓度与心功能的关系探讨  

A study on the correlations between plasma concentrations of N-terminal pro brain natriuretic peptide and cardiac function in patients with chronic heart failure

作　　者：德卫林[1] 杨建章[1] 于敏奇 

机构地区：[1]吉林市第二中心医院,吉林132001

出　　处：《中国地方病防治》2007年第2期154-155,共2页Chinese Journal of Control of Endemic Diseases

摘　　要：目的研究慢性心力衰竭患者血浆N末端脑钠素前体(NT-ProBNP)浓度与心功能分级的关系。方法酶联免疫法测定120例心脏病患者(心力衰竭组72例,无心力衰竭组48例)及34名健康体检者血浆NT-ProBNP浓度。结果充血性心力衰竭组血浆NT-ProBNP浓度显著高于健康体检者及无心力衰竭组,且随着心力衰竭程度的加重而显著增加(P<0.001)。结论血浆NT-ProBNP浓度是评价心功能的重要生化指标。Objective To study the correlations between plasma concentrations of N - terminal pro brain natriuretic peptide （ NT - proBNP） with cardiac function in patients with chronic heart failure. Methods Plasma NT - proBNP levels of patients with cardiac diseases （ n = 120） and of normal controls （ n = 34） were measured by enzyme - linked immunoassay. Results The plasma NT - proBNP concentrations of patients with chronic heart failure were significantly higher than those of the normal controls and the cases with non heart failure respectively. They also increased with the severity of cardiac failure according to NY-HA functional classification （ P 〈 0. 001）. Conclusion The plasma NT - proBNP concentration is a important biochemical parameter for evaluating heart function.

关 键 词：心力衰竭 充血性 脑钠素前体 

分 类 号：R541.6[医药卫生—心血管疾病]