大鼠初级听皮层神经元兴奋性频率反应域的特征  

Characteristics of frequency response areas of neurons in primary auditory cortex of rats

作　　者：张永海[1] 隋建峰[1] 刘国龙[1] 李志方[1] 熊鹰[1] 

机构地区：[1]第三军医大学基础医学部生理学教研室重庆市神经科学研究所,重庆400038

出　　处：《第三军医大学学报》2007年第7期576-578,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金(30371532)~~

摘　　要：目的探索大鼠初级听皮层神经元的兴奋性频率反应域的特征。方法应用细胞外记录方法,用钨丝微电极记录大鼠初级听皮层神经元的单位放电活动,并用Brainware分析软件采集得到该神经元的频率-强度反应域即兴奋性频率反应域。结果在大鼠初级听皮层共记录到106个神经元的单位放电活动,其最佳频率的范围从2～45kHz。根据神经元的兴奋性频率反应域形状的不同可将它们分为6类:U型(29.5%),V型(20%),低尾高锐型(19%),封闭型(15%),低频倾斜型(7.5%),多峰型(9%)。结论大鼠初级听皮层神经元的兴奋性频率反应域具有多种类型,而不同的兴奋性频率反应域的形成机制可能相同。Objective To investigate the characteristics of frequency response areas of neurons in the primary auditory cortex. Methods Extracellular multi-unit activities were recorded in the primary auditory cortex of the rats with tungsten microelectrodes. The frequency-intensity response areas were acquired and analyzed by the Brainware software. Results We recorded totally 106 neurons＇ activities from 15 SD rats. Their best frequencies ranged from 2 kHz to 45 kHz. According to the shape of the excitatory frequency response areas （ eFRA）, we could classify them into 6 classes, that is, U-shaped （29.5%）, V-shaped （20%）, lower-tailedupper-sharp （19%）, circumscribed （15%）, slant-lower （7.5%） and multi-peaked （9%）. Conclusion The shapes of the excitatory frequency response areas of the neuron in the primary auditory cortex are various and might result from the same mechanisms.

关 键 词：大鼠 初级听皮层 兴奋性频率反应域 

分 类 号：R338.3[医药卫生—人体生理学] R338.8[医药卫生—基础医学]