MIF在食管鳞癌组织和癌旁组织中的表达  

Expression of macrophage migration inhibitory factor in esophageal squamous cell carcinoma and normal esophageal tissue

作　　者：赵劲松[1] 廖克龙[1] 

机构地区：[1]第三军医大学西南医院胸心外科,重庆400038

出　　处：《第三军医大学学报》2007年第8期740-742,共3页Journal of Third Military Medical University

摘　　要：目的研究巨噬细胞移动抑制因子(MIF)在食管鳞状细胞癌组织和癌旁组织中的表达及与临床病理的关系。方法用免疫组化方法检测80例食管鳞癌标本和80例食管癌旁组织中MIF的表达水平。结果MIF在食管鳞癌组织中的表达呈明显增加,并与癌细胞的分化程度、肿瘤的TNM分期密切相关,MIF在癌旁组织的黏膜生发层细胞中表达也有少量的增加。结论MIF参与调节细胞的生长周期,在人食管鳞状细胞癌的发病机制中起着重要的作用,与食管鳞癌TNM分期有关。Objective To investigate the expression of macrophage migration inhibitory factor （MIF） in esophageal squamous cell carcinoma （ ESCC ） and in normal tissues around the esophageal cancer and determine whether there exists a relationship between MIF expression and clinicopathologic features. Methods The expression levels of MMIF in 80 ESCC specimens and 80 normal tissues around esophageal cancer by immunohistochemical staining. Results MIF was overexpressed in ESCC specimens and closely correlated with tumor differentiation and TNM staging. In normal esophageal tissues we found a small amount increment of MIF in the malpighian layer of mucous membrane. Conclusion MIF participates in the accommodation of cell growth cycle, plays an important role in the pathogenesis of ESCC and correlates with TNM staging.

关 键 词：巨噬细胞移动抑制因子 食管鳞癌 免疫组织化学 

分 类 号：R392.11[医药卫生—免疫学] R730.43[医药卫生—基础医学]