单硝酸异山梨酯口腔崩解片的制备及药剂学研究  

Preparation and study of pharmaceutics of 5-ISMN orally disintegrating tablets

作　　者：赵楠[1] 汤真[2] 王艳萍[2] 薛万俐[2] 

机构地区：[1]延边大学药学院,吉林延吉133000 [2]中国人民解放军第208医院,吉林长春130062

出　　处：《药学实践杂志》2007年第2期94-97,共4页Journal of Pharmaceutical Practice

摘　　要：目的:筛选单硝酸异山梨酯口腔崩解片的处方并考察片剂质量。方法:采用正交设计法筛选片剂处方,用HPLC法测定片剂的含量。结果:所得的优化处方为:MCC与L-HPC的比例为8:2(32%,8%),CC- Na为3%,甘露醇为15%,乳糖为31%。所得的片剂在20 s内完全崩解,1 min释药80%以上,口感良好。结论:选择合适的辅料,可以生产出崩解快、口感好,能够快速起效的口腔崩解片。Objectlve：To optimize the formulation of 5-ISMN orally disintegrating tablets, and inspect quality of prepared tablets. Methods：The orthogonal design was used and HPLC was used to determine the concentration. Results： Besides 5-ISMN, the tablets were composed of croscarmellose sodium 3%, mannite 15% , lactose 31% ,MCC/L-HPC ratio was 8： 2（32% ,8% ）. The prepared tablets disintegrated completely in 20s, dissolved more than 80% in 2 min and tasty fine. Conclusion： Choose properly excipients, we can produce orally rapidly-disintegrating tablets of rapidly disintegrating,tasty well and rapid absorption.

关 键 词：单硝酸异山梨酯 口腔崩解片 正交设计 

分 类 号：R944.9[医药卫生—药剂学]