5-氟尿嘧啶缓释化疗药代动力学研究  

Pharmacokinetical Study of 5-fluorouracil Based Sustained Rlease Chemotherapy

作　　者：李井泉[1] 赵平[1] 王世亮[2] 王成锋[1] 单毅[1] 赵东兵[1] 吴铁成[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院肿瘤研究所,北京市100021 [2]合肥工业大学控释药物研究室

出　　处：《中国全科医学》2007年第8期630-631,共2页Chinese General Practice

基　　金：国家科技十五攻关计划课题(2004BA703B11)

摘　　要：目的研究5-氟尿嘧啶缓释化疗的药代动力学特点。方法将30例消化道恶性肿瘤患者按5-氟尿嘧啶给药方法分为2组:5-氟尿嘧啶缓释化疗组15例,5-氟尿嘧啶全身化疗组15例。观察并比较两组患者5-氟尿嘧啶的半衰期(t1/2)、表观分布容积(Vd)及曲线下面积(AUC)。结果两组患者5-氟尿嘧啶的t1/2、Vd及AUC间差异均有统计学意义(P<0.01)。结论5-氟尿嘧啶缓释化疗的t1/2较全身化疗长,药物主要分布在肿瘤局部,血浆药物分布较少。Objective To study the pharmacokinetics of 5 -fluorouracil based sustained release chemotherapy. Methods 30 cases with malignant tumor of digestive tract were devided into two groups. Study group received 5 - fluorouracil based sustained release chemotherapy, while control group received systematic chemotherapy, Results 5 - fluorouracil based sustained release chemotherapy had high apparent volume of distribution, long half time and small area under the curve compared with systematic chemotherapy. Conclusion Sustained release chemotherapy can prolong the regional action time and improve the regional concentration of chemotherapeutic drugs.

关 键 词：氟尿嘧啶 迟效制剂 药代动力学 

分 类 号：R917[医药卫生—药物分析学]