灰绿黄堇生物总碱抗炎镇痛作用的研究  

Study on Anti-inflammatory and Analgesic Effects of Alkaloids of Corydalis Adunca Maxim

作　　者：张莉[1] 张芳[1] 王继生[1] 胡尚久[1] 刘太圣[1] 

机构地区：[1]四川省绵阳市第三人民医院,绵阳市621000

出　　处：《中国药房》2007年第12期888-889,共2页China Pharmacy

基　　金：四川省卫生厅科研项目(050267)

摘　　要：目的：研究灰绿黄堇生物总碱的药理活性及毒性,为进一步开发新药提供药理学依据.方法：对实验鼠分别以二甲苯、琼脂致肿,观察灰绿黄堇的抗炎作用;采用扭体法观察灰绿黄堇的镇痛作用;用改良寇氏法计算半数致死量（LD50）及95%可信限.结果：灰绿黄堇生物总碱制剂小鼠灌胃给药能抑制二甲苯所致耳肿胀和琼脂所致足肿胀,并能抑制酯酸所致小鼠扭体反应.其LD50为1.833g·kg^-1,95%可信限为1.18～2.06g·kg^-1.结论：灰绿黄堇总生物碱具有抗炎和镇痛作用.OBJECTIVE： To study the pharmacological activities and toxicity of the crude alkaloids of Corydalis adunca maxim and to provide pharmacological data for further development of this herbal medicine. METHODS： The anti- inflammatory effects of the crude alkaloids of Corydalis adunca maxim were observed by using xylol and agra to induce the turgidness in the rats. The analgesic effects were observed by body distortion methods. The LD50 and 95% creditability were calculated with developed Karber Method. RESULTS： The administration of alkaloids of Corydalis adunca maxim had the function of inhibiting the auricle swelling caused by xylol and joint swelling caused by agar, and of decreasing the body-distortion of the rats. The LDs0 of the crude alkaloids of Corydalis adunca maxim was 1.833g·kg^ -1 and the 95% creditability was 1.18- 2.06g · kg^ -1 CONCLUSIONS： The crude alkaloids of Corydalis adunca maxim has anti - inflammatory and analgesic effects in rats.

关 键 词：灰绿黄堇总生物碱 抗炎 镇痛 半数致死量 95%可信限 

分 类 号：R285.5[医药卫生—中药学]