Mu阿片受体多态性与海洛因依赖的关联研究  

The association of Mu opiate receptor gene polymorphism with heroin dependence

作　　者：杜江[1] 谢斌[1] 崔东红[1] 禹顺英[1] 汪东祥[1] 江三多[1] 赵敏[1] 张明园[1] 

机构地区：[1]上海市精神卫生中心,200030

出　　处：《临床精神医学杂志》2007年第2期73-75,共3页Journal of Clinical Psychiatry

基　　金：上海市卫生局课题资助项目(034031)

摘　　要：目的:探讨上海汉族人群中Mu阿片受体(OPRM1)基因A118G位点、C1031G位点多态性与海洛因依赖关联性。方法:采用病例对照研究,分别检测201名海洛因依赖者(依赖组)和249名健康对照(对照组)OPRM1基因A118G和C1031G位点基因型及等位基因频率,分析海洛因依赖者OPRM1受体基因多态与物质依赖的相关性。结果:A118G和C1031G位点多态性在依赖组和对照组间的分布差异无显著性;单体型分析两位点4种单体型均与海洛因依赖间无关联。结论:OPRM1基因A118G和C1031G位点与海洛因依赖无显著相关性。Objective：To explore the association between AIISG and C1031G polymorphism of Mu opiate receptor （OPRMI） gene and heroin dependence in Shanghai Han population. Method： In this case control study, the genotypes of OPRMI gene A118G allele and C1031G allele were detected in 201 heroin dependence patients （dependence group） and 249 controls （control group） and the association between heroin dependence and polymorphism of OPRMI gene was analyzed. Results： There were no significant difference in AIISG and C1031G gene polymorphism between the cases and the controls. Four haplotypes of the two locus were not related to heroin dependence respectively. Conclusion： There is no relationship between the polymorphism of OPRMI gene A118G locus and heroin dependence, also between the polymorphism of OPRMI gene C1031G locus and heroin dependence.

关 键 词：物质依赖 Mu阿片受体 

分 类 号：C913.8[经济管理]