益妇宁软胶囊的制备工艺研究  

Study on Preparation of Yifuning Soft Capsule

作　　者：王洛临[1] 宁德山 陈路林 邓虹珠[3] 

机构地区：[1]广东省中医研究所,广东广州510095 [2]广州汉方现代中药研究开发有限公司,广东广州510240 [3]南方医科大学中医系,广东广州510515

出　　处：《中国实验方剂学杂志》2007年第4期17-20,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:对益妇宁软胶囊的制备工艺进行研究。方法:采用药效学对莪术油及水提物进行筛选,试验证明莪术油为有效部位,以超临界萃取正交设计优化莪术油提取工艺条件;采用低温粉碎蛤蟆油;测定软胶囊的吸附基质数和量滴、考察助悬剂用量。结果:以萃取温度45℃、萃取压力22 MPa,萃取2.5 h可提高有效成分的提取率及疗效;蛤蟆油粉碎工艺条件为-20℃粉碎20 min。结论:该工艺科学合理,质量稳定,疗效确切。Objective： To study the best preparation process for Yifuning soft capsule. Methods： Taking pharmacodynamics results as the evaluation indexes to screening effective ingredients extracted from Rhizoma Curcumae, it was shown that oleum curcumae wenchowensis was the active situs; the SFE-CO2 extraction process of oleum curcumae wenchowensis were optimized by orthogonal design; subambient temperature technology was used to porphyrization Oviductus Ranae;the forming preparation parameters of soft elastic capsules, such as quantity of absorbing substance, suspending agent and minim were also determined. Results：The optimum preparation process of Yifuning soft capsule was following： the best extraction process of extracting Rhizoma Curcumae was 2.5 h, the temperature was 45 ℃ and the pressure was 22 MPa; the best porphyrization parameters were crashing Oviductus Ranae 20 min under the temperature -20℃. Conclusions：It was proved that this preparation process was reasonable and feasible

关 键 词：益妇宁软胶囊 制备工艺 正交设计 

分 类 号：R283.6[医药卫生—中药学]