甘草皂苷与桔梗皂苷合用的时间协同研究  

Combination of Saponins of Glycyrrhiza Uralensis Fisch(GS) and Platycodon grandiflorum A.DC(PS) for Duration of Effect

作　　者：刘彬[1] 齐云[1] 宋杨[1] 蔡润兰[1] 王敏[1] 谢忱[1] 罗秀珍[1] 

机构地区：[1]中国医学科学院中国协和医科大学药用植物研究所,北京100094

出　　处：《中国实验方剂学杂志》2007年第4期28-31,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：北京市自然基金资助课题(7042039);国家中医管理局资助课题(04-05ZL04)

摘　　要：目的:考查甘草皂苷与桔梗皂苷祛痰和抗炎作用的时间协同。方法:采用气管酚红排泌、二甲苯致耳肿胀及PLA2致足跖肿胀模型,考查两者合用对药效持续时间的影响,以及运用金氏Q值法对两者合用的相互作用性质进行定量评价。结果:甘草皂苷与桔梗皂苷合用可明显延长药效持续时间,Q值法评价显示出不同结果,随着时间延长,在气管酚红排泌模型中,由相加转为协同;在二甲苯致耳肿胀模型中,单用无效合用有效的时间点下,表现为相加和协同;在PLA2致足跖肿胀模型中,则表现为相加和拮抗。结论:甘草皂苷与桔梗皂苷合用在祛痰与抗炎方面具备时间协同特点,协同性质与两药配比、剂量有关。Objective：To evaluate the combination of saponins of Glycyrrhiza uralensis Fisch（GS） and Platycodon grandiflorum A. DC（PS） for duration of expectorant and anti-inflammatory effects. Methods： The duration of effects was observed directly in phenol drain model, xylene-induced mouse ear edema model and PLA2-induced mouse paw edema model, and the combinative effects of two agents was evaluated quantitatively by Jin＇ s Q formula. Results： Co- administration of GS and PS in 8： 1 can extend the duration of expectorant and anti-inflammatory effects, when compared to any agent alone. By the method of Jin＇s Q formula, additivity, synergism or antagonism was obtained in different models. Conclusions： GS and PS combined have characteristic of synergism in duration of expectorant and anti-inflammatory effects. The combinative ratio and total dose are two factors that can affect the combinative effects.

关 键 词：甘草皂苷 桔梗皂苷 祛痰 抗炎 金氏Q值法 时间协同 

分 类 号：R285.5[医药卫生—中药学]