化瘀通脉注射液对大鼠主动脉球囊损伤后内皮素-1、一氧化氮、黏附分子-1的影响  

Effects of Huayutongmai Injection on Endothelin-1,Nitric Oxide,Intercellular Adhesion Molecule-1 of Rat Aorta after Balloon Injury

作　　者：毛静远[1] 张宇[1] 李谈[1] 李明[2] 王恒和[1] 王占武[1] 张玉辉[2] 庄婷怡[2] 张运[1] 李红[1] 王强[1] 常延平[1] 张其梅[1] 吴慧轩[1] 

机构地区：[1]天津中医药大学第一附属医院,天津300193 [2]天津中医药大学,天津300193

出　　处：《中国实验方剂学杂志》2007年第4期48-50,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察化瘀通脉注射液对大鼠主动脉球囊损伤后内皮素-1(ET-1)、一氧化氮(NO)、黏附分子-1(ICAM-1)的影响。方法:大鼠96只,随机分为3组:化瘀通脉组、丹参组和生理盐水组。各组采用球囊内膜剥脱法复制大鼠主动脉内膜增殖动物模型,每组自造模前1 d开始,分别静脉注射化瘀通脉注射液、丹参注射液和生理盐水,于造模后第5,10,15,25 d每组各随机选取8只大鼠取血,检测各组血浆ET-1、NOI、CAM-1含量。结果:ET-1浓度在各组随时间的变化均有升高,化瘀通脉组明显低于其余两组;化瘀通脉组NO含量明显高于其余两组;化瘀通脉组ICAM-1含量明显低于其余两组。结论:化瘀通脉注射液具有降低血浆ET-1I、CAM-1及提高血浆NO水平的作用,这可能是其抑制大鼠主动脉球囊损伤后内膜增殖的部分机制。Objective： To study the effect of Huayutongmai Injection on interrelated factors of rat aorta after balloon injury. Methods：Total 96 Wistar rats were randomly divided into 3 groups： Huayutongmai, Danshen and normal saline ones, 32 rats in each. The rat model of intimal proliferation were copied by injuring aortic intima with self-made balloon, Huayutongmai Injection, Danshen Injection or normal saline was applied to the rats by intravenous rutine from the day before operation to the day before samples taken. Eight rats in each group were randomly killed and blood samples were drawn at 5,10, 15,25 days after injury. The blood content of endothelin-1 （ET-1 ）, nitric oxide （NO）, intercellular adhesion molecule- 1 （ ICAM- 1 ） were determined. Results： Compared with other two groups, the ET- 1 and ICAM- 1 were decreased and NO was increased in Huayutongmai group significantly. Conclusion： Huayutongmai Injection has the function of inhibiting intimal proliferation of rat arota after balloon injury. It could be related to lowering ET-1 and ICAM- 1, and increasing NO in blood.

关 键 词：化瘀通脉注射液 内膜增殖 内皮素-1 一氧化氮 细胞间黏附分子-1 

分 类 号：R285.5[医药卫生—中药学]