复方银杏丹参颗粒对异丙肾上腺素致心肌损伤的影响  

Effect of Yinxing-Danshen Granule on Myocardial Ischemic Injury Induced by Isoprenaline

作　　者：曹康[1] 陈光亮[1] 李莉[1] 

机构地区：[1]安徽中医学院药理教研室,安徽合肥230038

出　　处：《中国实验方剂学杂志》2007年第4期51-53,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察复方银杏丹参颗粒对异丙肾上腺素(ISO)致大鼠心肌损伤的影响。方法:采取大鼠皮下注射ISO(8 mg/kg)致急性心肌损伤模型,观察复方银杏丹参颗粒对大鼠注射ISO后不同时间J点下降情况,以及对血清乳酸脱氢酶(LDH)、肌酸磷酸激酶(CK)、丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性的影响。结果:复方银杏丹参颗粒35 g/kg、10.5 g/kg能明显抑制ISO引起的大鼠心电图J点下降,提高大鼠血清SOD活性、降低血清CK、LDH、MDA水平。结论:复方银杏丹参颗粒对ISO致大鼠心肌损伤模型具有明显保护作用。Objective： To observe the effect of Yinxing-Danshen Granule on myocardial ischemic injury induced by isoprenaline in rats, Methods：Rat myocardial ischemia was induced by subcutaneous injection of isoprenaline （8 mg/ kg）. The descent of J point at different time after injecting isoprenaline were examined, and the serum creatine kinase （CK） ,lactate dehydrogenase （LDH）, superoxide dismutase （SOD）and malondial dehyde （MDA）were detected. Result： Yinxing-Danshen Granule（35 g/kg, 10.5 g/kg） can obviously inhibit descent of J point in rat myocardial ischemia induced by isoprenaline, enhance serum SOD activity, and inhibit the activities of serum CK, LDH, and MDA. Conclusion： Yinxing-Danshen Granule may obviously ameliorate myocardial ischemic injury induced by isoprenaline in rat.

关 键 词：复方银杏丹参颗粒 异丙肾上腺素 J点 心肌损伤 

分 类 号：R285.5[医药卫生—中药学]