动脉粥样硬化大鼠弓状核ACTH免疫反应阳性神经元的变化  

THE CHANGES OF ACTH IMMUNOREACTIVE NEURONS OF THE ARCUATE NUCLEUS IN RATS WITH ATHEROSCLEROSIS

作　　者：吴开云[1] 赵培林[1] 

机构地区：[1]江西医学院解剖教研室,上海医科大学组胚教研室

出　　处：《神经科学》1996年第2期64-67,共4页Chinese Journal of Neuroscience

摘　　要：本文使用免疫细胞化学ＰＡＰ法和计算机图家分析技术，对动脉粥样硬化大鼠下丘脑弓状核ＡＣＴＨ免疫反应阳性细胞的变化进行了半定量研究，并对其阳性细胞的形态、数目和分布在光镜下进行了观察。结果表明：实验组，弓状核ＡＣＴＨ免疫反应阳性神经元比对照组明显减少（Ｐ＜０．０５），阳性细胞的积分光密度，实验组和对照组分别为０．１０２８±０．０３１和０．１２５０±０．０５１，本文从形态学角度提示了弓状核ＡＣＴＨ免疫反应阳性细胞对动脉粥样硬化的形成可能有一定影响。The changes of adrenocorticotropic hormone immunoreactive (ACTH-in) neurons of the hypothalamic arcuate nucleus in rats with atherosclerosis was studied semiquantitativly by immunocytochemical peroxidase-antiperoxidase (PAP) method and image analysis. The morphology, distribution n and number of ACTH-ir neurous were observed under microscope. The results showed that the number of ACTH-ir neruons in the experimental group was significantly lower than that in the control group. The average of the integral optical density (IOD) of positive weurons was 0.1028± 0.031 add 0.1250± 0.051 respectively in the experimental and control groups. From morphological point of view, it is suggested that the ACTH-ir peurons in the arcuate nucleus might have influence on development and/ or control of atherosclerosis.

关 键 词：弓状核 ACTH 免疫细胞化学 动脉粥样硬化 大鼠 

分 类 号：R543.502[医药卫生—心血管疾病]