孕早期环境因素与非综合征型总唇裂发生的相关性分析  

Association between environmental risk factor exposure in the first trimester and nonsyndromic cleft lip with or without cleft palate:a case-control study

作　　者：傅美华[1] 陈伟[2] 黄民主[2] 吴心音[2] 

机构地区：[1]中南大学湘雅二医院口腔科,湖南长沙410011 [2]中南大学公共卫生学院,湖南长沙410078

出　　处：《南方医科大学学报》2007年第4期436-438,共3页Journal of Southern Medical University

基　　金：湖南省计划生育委员会重点资助项目(2002-04)~~

摘　　要：目的研究儿童非综合征型总唇裂发生的主要环境影响因素,为预防其发生提供相关分析数据。方法采用以医院为基础的病例对照研究方法,对非综合征型总唇裂病例和对照的母亲进行问卷调查,应用SPSS13.0统计软件包对资料进行单因素分析和多因素非条件logistic回归分析。结果多因素分析结果显示:叶酸(OR=0.100,95%CI:0.032～0.312)有可能预防非综合征型总唇裂的发生;感染(OR=4.155,95%CI:2.166～7.970)、化学毒物接触(OR=6.816,95%CI:2.528～18.381)、情绪状况(OR=3.250,95%CI:1.477～7.154)是引起非综合征型总唇裂发生的危险因素。结论母亲妊娠早期感染、妊娠早期化学毒物接触和心情紧张是影响儿童非综合征型总唇裂的主要危险因素,加强妊娠早期叶酸的补充有可能降低发病的风险。Objective To identify the environmental risk factors during the first trimester responsible for nonsyndromic cleft lip with or without cleft palate to collect data for prevention of this congenital defect. Methods A hospital-based case-control study was conducted to identify the risk factors by means of field investigation with standardized questionnaires. Single factor analysis and logistic regression of the data are performed using SPSS 13.0 software. Results Multifactorial analysis revealed that folic acid was significantly associated with lowered incidence of nonsyndromic cleft lip with or without cleft palate （OR=0.100, 95%CI： 0.032-0.312）, whereas maternal infection （OR=4.155, 95%CI： 2.166-7.970）, poisonous chemical exposure （OR=6.816, 95%CI： 2.528-18.381） and emotional stress （OR=3.250, 95%CI： 1.477-7.154） were risk factors for this defect. Conclusions Sufficient follic acid intake and prevention of infection and poisonous chemical exposure during the first trimester are measures to reduce the risks ofnonsyndromic cleft lip with or without cleft palate.

关 键 词：唇裂 非综合征型 腭裂 危险因素 病例对照研究 

分 类 号：R715[医药卫生—妇产科学]