利多卡因酊剂和微乳制剂体外经皮渗透实验研究  

Comparison of transdermal permeation in vitro of lidocaine tincture and microemulsion

作　　者：黄亮[1] 陈志良[1] 李国锋[1] 朱晓亮[2] 刘婵[1] 

机构地区：[1]南方医科大学南方医院药学部,广东广州510515 [2]南方医科大学南方医院皮肤科,广东广州510515

出　　处：《南方医科大学学报》2007年第4期541-542,545,共3页Journal of Southern Medical University

摘　　要：目的比较经皮给药制剂的利多卡因微乳制剂与酊剂的皮肤渗透能力。方法采用改良的Franz扩散池,建立了利多卡因制剂的体外经皮渗透试验方法。结果利多卡因微乳单位面积累积透皮量高于利多卡因乳膏和酊剂单位面积累积透皮量。结论利多卡因微乳的体外透皮性优于利多卡因酊剂,且在一定范围内与含药量呈线形依赖关系。Objective To compare lidocaine tincture and microemulsion for their transdermal permeation, Methods The experimental model for percutaneous administration of lidocaine preparations in vitro was prepared using modified Franz diffusion cell. Results The accumulated infiltration amount oflidocaine microemulsion in unit area was higher than that in its cream or tincture preparations. Conclusion The transdermal permeation of lidocaine microemulsion in vitro can be more efficient than that of the tincture preparation, and the permeation is linearly dependent on the dose administered within a certain range.

关 键 词：利多卡因 微乳 酊剂 经皮给药制剂 

分 类 号：R944[医药卫生—药剂学]