川芎嗪对弥漫性轴索损伤患者凝血功能的影响  

Effect of Tetramethylpyrazine on Blood Coagulation of Patients with Diffuse Axonal Injury

作　　者：吴良贵[1] 王刚[1] 李宏伟[1] 麦荣康[1] 董临江[1] 

机构地区：[1]南方医科大学附属深圳宝安医院,深圳518101

出　　处：《血栓与止血学》2007年第2期80-81,共2页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨川芎嗪对弥漫性轴索损伤(diffuse axonal injury,DAI)患者凝血功能的影响。方法将62例确诊为DAI的患者随机分为常规治疗组(n=30)和川芎嗪治疗组(n=32),治疗前后测定凝血指标(血小板计数、凝血酶原时间、纤维蛋白原及D二聚体等),进行对比分析。结果DAI患者入院时血小板计数、凝血酶原时间、纤维蛋白原及D二聚体均高于正常。经川芎嗪治疗后,上述指标于1周内逐渐降至正常水平(P<0．05);而常规治疗组仍高于正常,与川芎嗪治疗组比较差异有显著性(P<0．05)。结论川芎嗪可显著改善弥漫性轴索损伤患者的凝血功能,有利于改善预后。Objective To explore the effect of tetramethylpyrazine on blood coagulation of patients with diffuse axonal injury （DAI）. Methods 62 patients with DAI were randomly into 2 groups. Group Ⅰ （ n = 30）received conventional therapy and group Ⅱ （n = 32 ） received conventional therapy plus Tetrameth- ylpyrazine treatment. Indices of blood coagulation such as platelets count, prothrombin time, fibrinogen and D-dimer were measured before and after therapy and the indices were compared. Results The platelets count, prothrombin time, the level of fibrinogen and D-dimer were significantly increased and were decreased to normal level in 1 week after Tetramethylpyrazine infusion intravenously （ P 〈 0.05 ）. The blood coagulation indices of group Ⅰ were significantly higher than that in group Ⅱ. Conclusion Tetramethylpyrazine can improve the function of blood coagulation and then improve the prognosis of patients with diffuse axonal injury.

关 键 词：弥漫性轴索损伤 凝血功能 川芎嗪 

分 类 号：R282.7[医药卫生—中药学]