阿托伐他汀对冠心病患者颈动脉内-中膜厚度的影响  

The influence of atorvastatin on intimal-medial thickness of carotid artery in patients with coronary artery disease

作　　者：杨丽平[1] 刘丽文[1] 钱蕴秋[1] 杨力军[1] 李兰荪[1] 何光彬[1] 周晓东[1] 沈敏[1] 

机构地区：[1]第四军医大学西京医院超声诊断科,陕西西安710032

出　　处：《西北国防医学杂志》2007年第2期104-106,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：陕西省科技攻关基金资助项目(2006K13-G1)

摘　　要：目的:应用高频超声观察冠心病(CAD)患者,经阿托伐他汀治疗后对颈动脉内-中膜(IMT)的改善作用。方法:经冠脉造影(CAG)确诊为CAD并伴有颈动脉粥样硬化患者59例,利用高频超声血管技术检测阿托伐他汀对CAD患者治疗前后颈动脉最厚处和最薄处IMT。结果:阿托伐他汀组治疗2年后,冠心病患者颈动脉IMT最厚处和最薄处与治疗前相比均无显著性改变(P>0.05);常规治疗组治疗2年后,颈动脉IMT最厚处与治疗前相比无显著性改变(P>0.05),IMT最薄处显著增厚(P<0.05)。结论:阿托伐他汀具有稳定斑块、延缓粥样硬化斑块进展的作用。Objective ：To observe the effect of atorvastatin on intimal - medial thickness （IMT） of carotid artery in patients with coronary artery disease （CAD） by high - frequency ultrasonic imaging. Methods： A total of 59 patients with CAD and carotid artery artherosclerosis diagnosed by coronary angiography （CAG） and high - frequency ultrasound were submitted to this study. High - frequency ultrasonic imaging was used to detect the changes of carotid artery IMT after administration of atorvastatin. Results： After atorvastatin therapy for 2 years, both thickest and thinnest IMT of carotid artery in CAD patients had no significant change （ P 〉 0.05 ）. In conventional therapy group, the thickest IMT of carotid artery had no significant change （P 〉 0.05 ）, but the thinnest IMT thickened significantly （P 〈 0.05 ）. Conclusion： Atorvastatin is effective to stabilize the plaque and retard the development of atherosclerosis.

关 键 词：超声波诊断 内-中膜厚度 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]