肝细胞生长因子与免疫调控  

Hepatocyte Growth Factor and Its Immunoregulatory Activity——Review

作　　者：边莉[1] 郭子宽[2] 艾辉胜[1] 

机构地区：[1]军事医学科学院附属医院血液科,北京100039 [2]军事医学科学院放射医学研究所,北京100071

出　　处：《中国实验血液学杂志》2007年第2期441-444,共4页Journal of Experimental Hematology

摘　　要：肝细胞生长因子(hepatocyte growth factor,HGF)是一种多功能细胞因子。近年来,对HGF在免疫系统生理与病理过程中的作用及其机制的研究不断深入,HGF的免疫调节效应逐渐被阐明。本文结合近几年国内外研究进展,就肝细胞生长因子在免疫调控中的作用,如HGF调控T、B淋巴细胞和树突状细胞等多种免疫细胞功能,调节特异性体液及细胞免疫应答,预防和治疗实验性异基因骨髓移植后并发的急性移植物抗宿主病,促进造血功能和免疫功能的恢复,在心、肝、肾等器官移植中发挥保护作用并促进组织再生,以及用于治疗自身免疫相关疾病等方面的研究结果进行了综述。Hepatocyte growth factor （HGF）is a pleiotropic cytokine, its roles in the physiology and pathology of immune system, have been investigated thoroughly, great deal of data have been documented on its immunoregulatory activity. In this review, according to advance of study on HGF in recent years, the role of HGF in the immune regulation, such as immunoregulatory effects of HGF on T lymphocytes, B lymphocytes and dendritic cell, modulation of HGF on specific humoral and cellular immune response, control of acute GVHD and acceleration of myeloid and immunologic reconstitution in allogentic bone marrow transplantation models, promotion of tissue repair and regeneration, and alleviation of immune rejection in allogeneic organ transplantation including the heart, liver and kidney transplantation, prevention of grafts from injury as well as applicably useful of HGF in the therapy of autoimmune disorders were summarized.

关 键 词：肝细胞生长因子 免疫调节 移植物抗宿主病 

分 类 号：R692[医药卫生—泌尿科学]