401例自然流产的免疫病因分析  

Analysis on 401 cases immunological factors of spontaneous abortion

作　　者：陈铁福[1] 张颖[2] 张秀玲[2] 李岩[2] 

机构地区：[1]天津市人民医院妇产科,天津300121 [2]天津医科大学总医院

出　　处：《天津医科大学学报》2007年第1期88-89,101,共3页Journal of Tianjin Medical University

摘　　要：目的:探讨免疫因素与自然流产的关系。方法:采用酶联免疫吸附实验(ELISA)对401例自然流产妇女进行血清抗精子抗体(ASAb)、抗卵巢抗体(AOAb)、抗子宫内膜抗体(EMAb)及抗绒毛膜促性腺激素抗体(HCGAb)的检测。结果:流产组106例ASAb阳性,阳性率为26.14%;96例AOAb阳性,阳性率为23.19%;102例EMAb阳性,阳性率为25.14%;92例HCGAb阳性,阳性率为22.19%。与对照组比较,差异均有高度显著性(P<0.005)。4种抗体联合检测,抗体的阳性率为40.00%,与单独检测ASAb、HCGAb、AOAb和EMAb相比,差异均有高度显著性(P<0.005)。结论:免疫因素是自然流产的不容忽视的因素,4种抗体的联合检测较单一抗体的检测阳性率高,对自然流产的临床诊治有一定的指导意义。Objective： Study on the relationship between spontaneous abortion and immunological factors. Methods： Serum antisperm antibody, anti-ovarian antibody, anti-endometrial antibody and anti- HCG antibody in 401 female patients with spontaneous abortion were tested. Results： The detective rates of the above antibodies were 26.14 %, 23.19 %, 25.14 % and 22.19 % respectively. There was a significant difference between the test spontanseous abortion group and control group.The detective rates of the four antibodies united was 40.00 %. There was a significant difference between the antibodies united test and single antibodie test. Conclusion： Spontaneous abortion is mainly related to immunological factors. United test of four antibodies is a valuabl method in spontaneous abortion.

关 键 词：自然流产 免疫病因 抗体 

分 类 号：R714.21[医药卫生—妇产科学]