有氧运动对老年高血压合并2型糖尿病患者血小板功能的影响  

Effect of Aerobic Exercise on Platelet Function in Elderly Patients with Hypertension and Type 2 Diabetes

作　　者：李玉峰[1] 王士雯[1] 赵玉生[1] 卢才义[1] 薛桥[1] 

机构地区：[1]解放军总医院老年心血管病研究所老年心血管病救治中心,北京市100853

出　　处：《中国康复理论与实践》2007年第4期391-392,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金：中央保健委员会专项基金重点资助课题资助(No.B020)

摘　　要：目的探讨有氧运动对老年高血压合并2型糖尿病患者血小板表面活化分子标记蛋白及血小板聚集率的影响。方法将81例老年高血压合并2型糖尿病患者随机分为常规治疗组41例和规律运动组40例，均给予常规治疗，后者在此基础上采取中等运动量运动疗法3个月。采用流式细胞术以单克隆抗体分子为探针，分别测定两组患者血小板膜上CD62P、CD61的阳性百分率及血小板聚集率。结果3个月后，常规治疗组与规律运动组患者的收缩压分别为（166±3.6）mmHg和（152±3.5）mmHg，舒张压分别为（93±4.2）mmHg和（83±4.3）mmHg；空腹血糖分别为（7.4±2.4）mmol/L和（6.3±1.9）mmol/L；血小板膜上CD62P阳性百分率分别为（27.3±2.2）%和（21.5±3.3）%，CD61阳性百分率分别为（26.3±2.3）%和（20.2±2.9）%；血小板聚集率分别为（78.4±4.5）%和（69.7±5.4）%，两组间差异有统计学意义（P〈0.05～0.01）。结论规律运动可以降低老年高血压合并2型糖尿病患者的血小板表面活化受体分子密度，降低血小板聚集率。Objective To explore the effect of aerobic exercise on platelet function in elderly patients with hypertension and type 2 diabetes. Methods 81 elderly patients with hypertension and type 2 diabetes were divided into the routine treatment group （group A, n=41） and regular exercise group （group B, n=40）. All patients of two groups were treated with routine treatment. The exercise with moderate intensity was performed in the group B for 3 months besides routine treatment. The platelet membrane glycoprotein CD62P, CD61 （Ⅲa） were detected by flow cytometric analysis and platelet aggregating ratio was measured before and after regular aerobic exercise. Results After three months, the systolic blood pressures were 166±3.6 mm Hg （group A） and 152±3.5 mm Hg （group B）; the diastolic blood pressures were 93±4. 2 mm Hg （group A） and 83±4.3 mm Hg （group B）; the contents of blood glucose were 7.4±2.4 mmol/L （group A） and 6.3±1.9 mmol/L （group B）, the positive percents of platelet membrane glycoproten CD62P were 27.3±2.2% （group A） and 21.5±3.3% （group B）, CD61（Ⅲa） were 26.3±2.3% （group A） and 20. 2±2. 9% （group B） and platelet aggregation rates were 78.4±4. 5% （group A） and 69.7±5.4% （group B）, there was a significant difference between two groups （ P 〈0. 05～0. 01）. Conclusion Regular aerobic exercise can decrease the positive percent of platelet membrane glycoprotein and platelet aggregation rate in elderly patients with hypertension and type 2 diabetes.

关 键 词：高血压病 有氧运动 2型糖尿病 血小板膜糖蛋白受体 老年人 

分 类 号：R411.712[医药卫生—临床医学] R415.382