光动力疗法治疗湿性年龄相关性黄斑变性脉络膜新生血管膜的临床效果  

Clinical study of photodynamic therapy for exudative age-related degeneration

作　　者：张风[1] 周海英[1] 熊颖[1] 高丽琴[1] 陈轶[1] 

机构地区：[1]首都医科大学北京同仁眼科中心,100730

出　　处：《中华眼科杂志》2007年第4期350-354,共5页Chinese Journal of Ophthalmology

基　　金：首都医学科技发展基金资助项目（2002-1019）

摘　　要：目的探讨光动力疗法（PDT）对湿性年龄相关性黄斑变性（AMD）患者脉络膜新生血管（CNV）膜的临床疗效。方法回顾性分析2000年8月至2006年2月经PDT治疗后随访≥6个月的93例（98只眼）湿性AMD患者的临床效果，比较其治疗前后的视力、荧光素眼底血管造影（FFA）及吲哚氰绿眼底血管造影（ICGA）图像特征。结果PDT治疗后6个月，患者视力稳定不变的有59只眼（60．2％），视力提高的有21只眼（21．4％），视力下降的有18只眼（18．3％）。经FFA检查发现CNV复发且重复治疗者有54只眼（55．1％）；重复治疗时间：1个月者1只眼，3个月者24只眼，6个月者15只眼，9个月者6只眼，〉12个月者8只眼。54只眼重复治疗次数：2次40只眼，3次12只眼，4次2只眼，平均治疗次数为1．7次。随访时间：6—58个月，平均14个月。所有病例均未见严重的不良反应。结论PDT是治疗CNV的安全、有效方法，但需反复治疗。Objective To evaluate the effects of photedynamic therapy on subfoveal choroidal neovascularization （CNV） in patients with age-related macular degeneration （AMD）. Methods 93 patients （98 eyes） with subfoveal CNV secondary to AMD treated with verteporfin PDT from August 2000 to February 2006 were retrospectively analyzed. All patients received verteportin PDT and were followed clinically with visual acuity testing, fundns fluorescein angiography （FFA） and indocyaine green angiography （ICGA）. Rrsults The visual acuity was stabilized in 59 eyes （60. 2% ）, improved in 21 eyes （ 21.4% ）, and decreased in 18 eyes （ 18.3% ） 6 months after PDT. 54 patients （54 eyes, 55. 1% ） received multiple sessions of PDT because the recurrence of CNV leakage. The intervals of additional courses of treatment were variable from 1 month （ 1 eye）, 3 months （24 eyes） , 6 months （ 15 eyes）, 9 months （ 6 eyes） to more than 12 months （8 eyes）. 40 eyes received two sessions, 12 received three courses and 2 received 4 times repeated treatment. All patients received the 1.7 treatments in average. The Mean time of follow-up was 14 months （6 -58 months）. No serious side effect was recorded. Condusions PDT is a safe and effective treatment for patients with CNV from AMD, however, retreatments are required.

关 键 词：黄斑变性 脉络膜新生血管化 光化学疗法 

分 类 号：R686[医药卫生—骨科学]