玫瑰糠疹与HHV-7感染的相关性及外周血T淋巴细胞亚群的研究  

The study on the relationship between pityriasis rosea and HHV-7 infection and the change of T cell subsets in peripheral blood

作　　者：张文霞[1] 王桂芝[1] 

机构地区：[1]青岛大学医学院附属医院皮肤科

出　　处：《中国麻风皮肤病杂志》2007年第4期277-279,共3页China Journal of Leprosy and Skin Diseases

摘　　要：目的:探讨玫瑰糠疹发病与人类疱疹病毒-7(HHV-7)的关系及外周血T淋巴细胞亚群的变化。方法:用PCR和免疫组化的方法研究了玫瑰糠疹发病与HHV-7的关系及外周血T淋巴细胞亚群比例的变化。结果:玫瑰糠疹患者HHV-7阳性率(88.89%)明显高于健康对照组(52.78%,χ2=9.68,P<0.01);玫瑰糠疹患者CD3+比例明显低于健康对照组(t=5.09,P<0.01),CD4+比例低于健康对照组(t=2.07,P<0.05),CD8+比例明显高于对照组(t=4.76,P<0.01),CD4+/CD8+比例与对照组相比明显降低(1.12:1.30,t=4.31,P<0.01);HHV-7感染者CD4+/CD8+值明显低于HHV-7非感染者(Z=4.9525,P<0.001)。结论:玫瑰糠疹的发病可能与HHV-7感染后引起的细胞免疫反应有关。Objective： To investigate the relationship between pityriasis rosea （PR） and human herpes virus 7 （HHV- 7） and the change of T cell subsets. Methods： Polymerase chain reaction （PCR） with specific primers for HHV- 7 DNA sequences was performed on each blood sample and T cell subsets were measured by SAP. Results： There was statistically significant difference in the presence of HHV - 7 sequence between the PR patients and the controls （88.9 % vs 52.78 %, P 〈 0.01 ）. The proportions of CD3 ^＋ T cell and CD4^＋ T cell were significantly lower in PR patients than in controls （ P 〈 0.01 and P 〈 0.05, respectively）, while the proportion of CD8^＋ T cell was significantly higher in the PR patients than in controls （ P 〈 0.01 ）. The ratio of CD4^＋ to CD8^＋ was significantly lower in the PR patients than in the controls （ P 〈0.01）. The ratio of CD4^＋ to CD8^＋ was significantly lower in the HHV- 7 positive patients than in negative ones （P 〈 0.001 ）. Conclusion： Cell- mediated immunity reaction after HHV- 7 infection may be involved in the pathogenesis of PR.

关 键 词：玫瑰糠疹 人类疱疹病毒-7 PCR T淋巴细胞亚群 免疫组化 

分 类 号：R758.64[医药卫生—皮肤病学与性病学]