伊曲康唑治疗不同免疫状态下小鼠白念珠菌性阴道炎的实验研究  

The experimental study of itraconazole against vaginal candidiasis under different immune conditions in mice

作　　者：陈善娟[1] 刘志香[1] 吴艳[1] 涂亚庭[1] 李家文[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院皮肤性病科,武汉430022

出　　处：《中国麻风皮肤病杂志》2007年第4期293-295,共3页China Journal of Leprosy and Skin Diseases

基　　金：湖北省卫生厅科研基金资助项目(NO.JXIB048);杨森科学研究基金项目

摘　　要：目的:研究不同免疫状态下伊曲康唑治疗小鼠白念珠菌性阴道炎的疗效。方法:构建ICR小鼠白念珠菌性阴道炎模型,并应用地塞米松构建免疫抑制鼠模型;采用伊曲康唑灌服治疗;其中F组同时采用γ-IFN治疗,在灌药后不同时间动态观察阴道灌洗液真菌载量。结果:伊曲康唑治疗正常免疫组(A组)与对照组(D组)之间的疗效差异有显著性(P<0.01);免疫抑制组(E组)及免疫抑制后并进行免疫调节治疗组(F组)与对照组(G组)之间差异均有显著性(P<0.01);而A、E、F组在接种后的第5、6、7、9、11天其阴道灌洗液真菌载量无明显差异(P>0.05)。结论:伊曲康唑治疗不同免疫状况(即正常免疫、免疫抑制、免疫调节治疗状态下)的小鼠白念珠菌性阴道炎疗效均显著,而且正常免疫、免疫抑制及免疫增强状态下对伊曲康唑的抗真菌疗效无明显影响。Objective： To determine the efficacy of itraconazole against vaginal candidiasis under different immune conditions in mice. Methods： ICR murine vaginal candidiasis models with normal immune system （group A） and dexamethasome- induced immunosuppressed （group E） were established. The mice were fed with fluid containing itraeonazole or IFN- γ. Results： The efficacy of itraconazole （A group） against vaginal candidiasis was higher than that of control group （P 〈 0.01 ）. The differences in efficacies between immunosuppressed group （group E）, immunoregulated group （group F） and control group were statistically significant （ P 〈 0.01 ）. There were no significant differences in average levels of colony forming unit （CFU） of group A, E, F at day 5, 6, 7, 9, 11 after inoculation （ P 〉 0.05）. Conclusion ： Itmconazole is effective in the treatment of vaginal candidiasis under different immune conditions （group A, E, F） in mice, with no significant difference in efficacy among the three groups.

关 键 词：念珠菌病 动物模型 免疫抑制 伊曲康唑 

分 类 号：R711.3[医药卫生—妇产科学]