TNF-α IL-6与妊娠高血压综合征相关性研究  

Relationship between interleukin-6,tumor necrosis factor-α and the pathogenesis of pregnancy-induced hypertension

作　　者：王娟[1] 吴素芳[1] 许少群[1] 

机构地区：[1]揭阳市人民医院,广东揭阳522000

出　　处：《基层医学论坛（B版）》2007年第5期396-397,共2页Public Medical Forum Magazine

摘　　要：目的探讨肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)与子痫前期-子痫患病关系。方法采用放射免疫方法检测70例妊娠高血压综合征患者(研究组)及52例正常健康孕妇(对照组)血清TNF-α、IL-6水平。结果研究组血清TNF-α(1.39±0.21)ng/L、IL-6(141.92±72.46)ng/L均明显高于对照组,差异有统计学意义(P<0.05)。结论TNF-α、IL-6参与了妊高征的血管内皮损伤过程,两种细胞因子的升高与妊高征的发生密切相关。Objective Our aim was to study the relationship between interleukin-6（IL-6）, tumor necrosis factor （TNF-α ） and the pathogenesis of pregnancy-induced hypertension （PIH）.Methods Radioimmunoassay was used to detect the levels of IL-6 and TNF-α in maternal serum of seventy woman with PIH （the study group）and fifty-two healthy pregnant women （thecontrolgroup）.Results The levels of TNF- α（1.39±0.21ng/L） and IL-6 （141.92±72.46 ng/L）in maternal serum in severe PIH were significantly higher than those in normal pregnant group （p）. Conclusions The TNF- α and IL-6 took part in the damage process of vascular endothelial cell. The increasing levels of the two cytokines were significantly relative to the pathogenesis of PIH.

关 键 词：肿瘤坏死因子Α 白细胞介素6 妊娠并发症 高血压 心血管 

分 类 号：R442.2[医药卫生—诊断学]