槲皮素抗实验性心律失常作用的研究  

Effects of quercetin on experimental arrhythmias

作　　者：张明爽[1] 徐长庆[1] 王秀丽[1] 杨金霞[1] 张卓然[1] 吴博[1] 高秀香[1] 张力[1] 张伟华[1] 杨宝峰[2] 

机构地区：[1]哈尔滨医科大学病理生理学教研室,黑龙江哈尔滨150081 [2]哈尔滨医科大学药理学教研室,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2007年第2期115-117,121,共4页Journal of Harbin Medical University

基　　金：黑龙江省科技厅国际合作课题(WC02303)

摘　　要：目的观察槲皮素抗实验性心律失常的作用,并探讨其可能机制。方法应用乌头碱,氯化钙制备大鼠心律失常模型,哇巴因制备豚鼠心律失常模型,观察槲皮素不同剂量对上述模型的保护作用。结果槲皮素(0.2mg/kg,0.4mg/kg)能提高乌头碱致大鼠和哇巴因致豚鼠发生室性早搏(VE)、室性心动过速(VT)、室颤(VF)的用量;延长氯化钙诱发大鼠心律失常出现的时间,缩短心律失常持续时间,减少心律失常发生率及死亡率。结论槲皮素具有抗多种实验性心律失常的作用。Objective To observe the effect of quereetin on experimental arrhythmias and to explore its possible mechanisms. Methods The rat arrhythmia models were induced by aconitine and CaCl2, the ginuea pig arrhythmia models were caused by ouabain, and the effects of quercetin with different doses on those models were investigated. Results Quercetin （ in 0.2 - 0.4mg/kg） increased the threshold doses of ventricular ectopic （VE） ,and ventricular tachyacardia （VT）, ventricular fibrillation （VF）, delayed the onset time of arrhythmia, shortened the duration time of arrhythmia, and decreased the incidence and death rate of rats with arrhythmia induced by CaCl2. Conclusion Quercetin possesses extensive protective effects on arrhythmia.

关 键 词：槲皮素 乌头碱 哇巴因 大鼠 豚鼠 心律失常 

分 类 号：R282.71[医药卫生—中药学] R965[医药卫生—中医学]