血管内皮生长因子C和受体3在子宫内膜异位症的表达及意义  

Expression and significances of vascular endothelial growth factor-C and its receptor-3 in patients with endometriosis

作　　者：蒋红清[1] 李亚里[1] 陈浩[2] 汪淑娟[1] 邹杰[1] 

机构地区：[1]解放军总医院妇产科 [2]军事医学科学院放射与辐射医学研究所免疫学研究室,北京100850

出　　处：《军医进修学院学报》2007年第2期99-101,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：全军十五重点课题基金资助项目(01Z032)

摘　　要：目的:探讨血管内皮生长因子C(VEGF-C)和其受体3(VEGFR-3)在子宫内膜异位症(EMs)中的表达及其在EMs发病机制中的作用。方法:收集32例EMs患者的卵巢子宫内膜异位病灶组织、32例在位内膜组织和25例正常子宫内膜组织(对照组),应用免疫组化两步法检测各标本中的VEGF-C和VEGFR-3的表达,并用组织学评分对实验结果进行半定量统计,比较其表达强度。结果:VEGF-C在EMs组在位、异位内膜和对照组均有表达,表达强度差异无统计学意义(P>0.05);VEGFR-3在EMs组在位和异位内膜的表达明显高于对照组(P<0.05),且在位内膜的表达明显高于异位内膜(P<0.05)。结论:VEGF-C与其受体VEGFR-3结合参与了EMs病程,并可能通过促淋巴管新生作用而促进了EMs的发生发展。Objective：To investigate the expression of VEGF-C and VEGFR-3 in endometriosis and the relationship between vascular endothelial growth factor and the mechanism of endometriosis. Methods. A total of 32 specimens of endometriosis and 25 specimens of the normal controls were evaluated by immunohistologically technique with polyclonal antibody against VEGF-C and VEGFR-3. Results：VEGF-C expressed express either in normal endometrium or eutopic and ectopic endometrium of endometriosis. There were no significant differences between them （P 〉 0.05 ）. The expression levels of VEGFR-3 in eutopic and ectopic endometrium of endometriosis were significantly higher than that of normal endometrium （P 〈 0.05）. The expression of VEGFR-3 in eutopic endometrium was higher than that in ectopic endometrium （P 〈 0.05 ）. Conclusion. VEGF-C and VEGFR-3 play significant roles in the regulation of lymphangiogenesis of endometriosis, which express in both eutopic endometrium and ectopic endometrium of endometriosis. VEGF-C and VEGFR-3 may play vital roles in the pathogenesis and development of endometriosis.

关 键 词：血管内皮生长因子C 血管内皮生长因子受体3 子宫内膜异位症 

分 类 号：R711.71[医药卫生—妇产科学]