药物中间体4-羧酸乙酯哌啶的合成  

Synthesis of Medicine Intermediate 4-Ethyl Formate Piperidine

作　　者：杨晓章 蒋忠良[2] 杜晓超[2] 

机构地区：[1]浙江天台药业有限公司,浙江台州317200 [2]同济大学化学系,上海200092

出　　处：《精细与专用化学品》2007年第8期18-19,共2页Fine and Specialty Chemicals

摘　　要：以4-哌啶甲酸和乙醇为原料,分别通过与二氯亚砜和三甲基氯硅烷反应两种不同的酯化方法制备药物中间体4-羧酸乙酯哌啶,产率分别为85.0%和92.7%,纯度均达到99%。并讨论了三甲基氯硅烷用量及反应温度等因素对反应的影响,获得了适宜的反应条件。Using piperidine-d-carboxylic acid and ethanol as raw material, d-ethyl formate piperidine was synthesized through esterification reaction with thionyl chloride and trimethylchlorosilane respectively, the yield was 85.0% and 92.7% correspondingly, the purity both reached 99%. Meanwhile, the amount of trimethychlorosilane and reaction temperature in- fluencing on the reaction were discussed, and the optimum reaction conditions were Obtained.

关 键 词：4-哌啶甲酸 二氯亚砜 乙醇 三甲基氯硅烷 

分 类 号：TQ253.2[化学工程—有机化工]