胃肠道间质瘤103例预后分析  

Prognosis of gastrointestinal stromal tumors:a study of 103 cases

作　　者：杜春燕[1] 师英强[1] 傅红[1] 赵广法[1] 周烨[1] 蔡国响[1] 

机构地区：[1]复旦大学附属肿瘤医院腹外科,上海200032

出　　处：《中国实用外科杂志》2007年第4期297-299,共3页Chinese Journal of Practical Surgery

摘　　要：目的探讨影响胃肠道间质瘤(GIST)预后的因素。方法回顾性分析1998年1月至2004年5月,复旦大学附属肿瘤医院腹外科收治的103例GIST临床病理及随访资料。进行Flecther恶性潜能分级,用寿命表法绘制总生存曲线,采用Kaplan-Meier法比较不同因素对生存的影响,并用Cox多因素回归分析对该组病例进行预后分析。结果所有病人的1年、3年、5年存活率分别为86.3%、51.7%、42.8%。生存分析比较肿瘤大小、核分裂象数目、手术性质是否为根治以及肿瘤原发部位差异均具有显著性意义(P<0.05),而性别、年龄、免疫组化表达情况、是否联合脏器切除差异无显著性意义。结论用Flecther恶性潜能分级方法来判断间质瘤的生物学行为和预测间质瘤的预后是合理、科学、简单、可行的方法,根治性手术仍是目前原发GIST的首选治疗,靶向治疗将成为治疗间质瘤的重要手段。Objective To investigate the prognostic factors of gastrointestinal stromal tumors. Methods The clinicopathological data of 103 patients with gastrointestinal stromal tumors admitted between January 1998 and May 2004 in Affiliated Cancer Hospital of Fudan University were analyzed restrospectively. Life table, kaplan-meier survival rate and cox regression model were used to evaluate the prognostic factors. Results The 1 year,3 years and 5 years total survival rate of 103 patients were 86. 3% ,51.7% ,42. 8% respectively. Tumor size, Mitotic rate, primary organ of tumor and radical surgical excision or not were analyzed respectively. The differences were significiant（ P 〈 0. 5 ）. No significiant differences in sex, age,immunohistochemistry expression and multi-organ resection or not were existed between the groups. Conclusion Flechers＇ classification is ratinal, scientific,simple and feasible. Radical surgical excision is the best therapy to the primary gastrointestinal stomal tumor.

关 键 词：胃肠道间质瘤 预后因素 靶向治疗 

分 类 号：R6[医药卫生—外科学]