Multi-channel neural signal stimulating module and in-vivo experiments  

多通道神经信号激励模块的研制及其动物实验(英文)

作　　者：李文渊[1] 王志功[1] 吕晓迎[2] 顾晓松[3] 张震宇[1] 

机构地区：[1]东南大学射频与光电集成电路研究所,南京210096 [2]东南大学生物电子学国家重点实验室,南京210096 [3]南通大学江苏省神经再生重点实验室,南通226001

出　　处：《Journal of Southeast University(English Edition)》2007年第1期26-30,共5页东南大学学报（英文版）

基　　金：The National Natural Science Foundation of China(No69825101,90377013)

摘　　要：The module for function electrical stimulation （FES） of neurons is designed for the research of the neural function regeneration microelectronic system, which is an in-body embedded micro module. It is implemented by using discrete devices at first and characterized in vitro. The module is used to stimulate sciatic nerve and spinal cord of rats and rabbits for in-vivo real-time experiments of the neural function regeneration system. Based on the module, a four channel module for the FES of neurons is designed for 12 sites cuff electrode or 10 sites shaft electrode. Three animal experiments with total five rats and two rabbits were made. In the in-vivo experiment, the neural signals including spontaneous and imitated were regenerated by the module. The stimulating signal was used to drive sciatic nerve and spinal cord of rats and rabbits, successfully caused them twitch in different parts of their bodies, such as legs, tails, and fingers. This testifies that the neural function regeneration system can regenerate the neural signals.为了研究植入式神经功能再生微电子系统,设计了功能激励神经信号产生模块.首先用分立器件设计并实现了体外应用的单通道功能激励神经信号产生模块,并将该模块成功应用于激励老鼠和兔子的坐骨神经和脊椎神经的神经功能再生微电子系统的动物试验.在此基础上,设计了用于12个电极点的卡肤电极或者10个电极点的剑状电极四通道神经信号激励模块.用5只老鼠和2只兔子进行了3次坐骨神经和脊髓神经束活体动物试验.试验中,功能激励神经信号产生模块再生了大鼠体内的自发神经信号和模拟的神经信号,模块所产生的信号使大鼠和兔子的腿部、尾巴甚至脚趾产生了相应的动作,验证了神经功能再生微电子系统的可行性.

关 键 词：MICROELECTRODE neural function regeneration function electrical stimulation neural signal channel STIMULATION 

分 类 号：R318[医药卫生—生物医学工程] TP274[医药卫生—基础医学]