盐酸阿扎司琼在家兔体内的药代动力学研究  

Study on pharmacokinetics in vivo of azasetron hydrochloride in rabbits

作　　者：熊雯[1] 张丹[2] 

机构地区：[1]成都市食品药品检测中心,成都610045 [2]四川大学华西药学院,成都610041

出　　处：《药物分析杂志》2007年第3期332-334,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:进行盐酸阿扎司琼在家兔体内的药代动力学研究。方法:采用 HPLC 法测定家兔经腹腔注射盐酸阿扎司琼氯化钠注射液(5 mg·kg^(-1)体重)后在家兔体内的血药浓度,得出药-时曲线图及相关药动学参数。结果:盐酸阿扎司琼在家兔体内过程符合二室模型。结论:家兔单剂量腹腔注射盐酸阿扎司琼氯化钠注射液后,能迅速被吸收,达峰时间短,吸收速度快,分布快,消除速度快。本研究结果可为本品临床合理用药提供参考,并为盐酸阿扎司琼的相关剂型研究提供药物体内研究资料。Objective：The pharmacokinetics of azasetron hydrochloride in rabbits in vivo were investigated in this report. Method：HPLC was used to estimate the blood concentration of azasetron hydrochloride in rabbits after caudal vein （5 mg · kg^-1 weigh） and blood concentration - time curves as well as pharmacokinetics parameters correlated were arrived at. Results ：The concentration -time curve of azasetron hydrochloride in rabbit plasma could be fitted to two - compartment model. Conclusion： Azasetron hydrochloride was absorpted into blood and eliminated quickly. These findings could provide reference for clinical rational administration, moreover offer medical data in vivo for studying azasetron hydrochloride＇ s correlated dosage forms.

关 键 词：盐酸阿扎司琼 药代动力学 家兔 HPLC 

分 类 号：R917[医药卫生—药物分析学]