不稳定型心绞痛患者血运重建后可溶性细胞间粘附分子-1的变化及临床意义  

Clinical evaluation of the level of sICAM-1 in unstable angina pectoris cases after percutaneous coronary intervention

作　　者：韩艳丽[1] 王营[1] 李继福[2] 姜红菊[1] 左岩霞[1] 朱靖[1] 王健[1] 刘芳[1] 纪求尚[2] 

机构地区：[1]山东中医药大学第二附院心内科,山东济南250001 [2]山东大学齐鲁医院心内科

出　　处：《心血管康复医学杂志》2007年第2期126-128,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨不稳定型心绞痛患者经皮冠状动脉介入治疗后可溶性细胞间粘附分子-1(sICAM-1)的变化及临床意义。方法:连续观察35例(A组)不稳定心绞痛患者经皮冠脉介入治疗术前及术后1h、24h、72h血液中sICAM-1的变化。另设单纯行冠脉造影的不稳定心绞痛患者30例(B组)和健康者30例(C组)作对照。酶联免疫吸附双抗体夹心法测定血浆sICAM-1含量,并随访术后3个月心血管事件的发生情况。结果:sICAM-1在A、B组的浓度明显高于C组,P<0.05;A组sICAM-1在术后1h开始升高,24h达峰值,P<0.05,于72h回落到正常水平;B组术前与术后无明显变化,P>0.05。结论:不稳定型心绞痛患者介入治疗后sICAM-1在72h内有动态变化,应注意相应治疗。Objective： To evaluate the change and significance of level of soluble intercellular adhesion molecule-1 （sI- CAM-1） in unstable angina pectoris （UAP） patients after percutaneous coronary intervention （PCI）. Methods： sI- CAM- 1 was tested in 35 UAP patients （A group） before and lh, 24h, 72h after PCL, 30 UAP patients （B group） who were performed of coronary angiography and 30 normal individuals （C group） entered this study as contrasts. All the UAP patients were followed up for 3 months. Results： Level of sICAM in UAP cases （A, B group） significantly increased compared with the normal individuals （C group）, P〈0. 05. It had a further increase （P〈0. 05） at 24 h after PCI, and resumed to the level before PCI after PCI 72 h. Conclusion： The level of sICAM-1 in UAP cases significantly increased after PCI, must adopted the corresponding therapy .

关 键 词：血管成形术 经腔 经皮冠状动脉 心绞痛.不稳定性 可溶性细胞间粘附分子-1 

分 类 号：R541.409[医药卫生—心血管疾病]