头孢他啶联合奈替米星或左氧氟沙星治疗老年医院获得性肺炎的对照观察  

Controlled observation of elderly hospital acquired pneumonia treated with ceftazidine combined with netilmicin sulfate or L-ofloxacin

作　　者：丛燕[1] 赵沄[1] 李音[1] 

机构地区：[1]复旦大学附属华东医院急诊科,上海200040

出　　处：《老年医学与保健》2007年第2期98-99,共2页Geriatrics & Health Care

摘　　要：目的 观察头孢他啶联合奈替米星治疗老年医院获得性肺炎（Hospital acquired pneumonia）的疗效。方法 将42例病人随机分为两组，治疗组22例，予头孢他啶2．0g静滴，每日2次；同时予奈替米星0．2～0．3g静滴，每日11次。对照组20例予头孢他啶2．0g静滴，每日2次；同时予左氧氟沙星0．5g静滴，每日1次。疗程均为7-14d。结果 治疗组与对照纽的有效率分别为81．8％和80％；两组的细菌清除率分别为84．6％和83．3％；药物不良反应发生率分别为13、6％和10％，两组比较均无统计学意义（P〉0．05）。结论 头孢他啶联合奈替米星治疗老年医院获得性肺炎安全、有效。Objective To evaluate the clinical eiticacy of ceftazidime combined with netilmicin sulfate in treatment of hospital acquired pneumonia in elders. Methods 42 patients were divided into two groups at random. 22 cases in the treated group were administered with ceftazidime combined with netilmicin sulfate. The dosage of ceftazidime was 2 g, twice daily intravenously; the dosage of netilmicin was 0.2-0.3 g, once daily intravenously. 20 cases in control group were received cefiazidime combined with levofloxacin, the dosage of cefiazidime was 2 g ,twice daily intravenously; the dosage of levofloxacin was 0.5g ,once daily intravenoesly .The duration of treatment was 7-14 d for either of both groups. Results The efficacy rates were 81.3% vs 80% for treated group and control group respectively, the bacterial clearance rates were 84.6% vs 83.3%. The adverse drug reaction rates were 13.6% vs 10%, respectively. There were no statistical differences between the two groups, Conclusions Ceftazidime combined with netilmicin sulfate is effective and safe for the treatment of hospital acquired pneumonia in elders.

关 键 词：头孢他啶 奈替米星 肺炎 交叉感染 

分 类 号：R563.1[医药卫生—呼吸系统]