Ru(bipy)_3^(2+)-Ce(Ⅳ)化学发光体系检测氢氯噻嗪  

Determination of Hydrochlorothiazide with Ru(bipy)_3^(2+)-Ce(Ⅳ) Chemiluminescence System

作　　者：李琳[1] 郁丰善[2] 陈芳[2] 

机构地区：[1]湖北省化学研究院,湖北武汉430074 [2]华中科技大学化学系,湖北武汉430074

出　　处：《武汉大学学报（理学版）》2007年第2期137-140,共4页Journal of Wuhan University:Natural Science Edition

基　　金：华中科技大学理科基金资助项目(0101013008)

摘　　要：基于氢氯噻嗪对三(2,2′-联吡啶)钌(Ⅱ)(Ru(bipy)32+)-Ce(Ⅳ)化学发光体系的增强作用,构建了一种化学发光直接检测氢氯噻嗪的新方法.在优化的实验条件下,该方法的线性范围和检出限分别为5.0×10-3~2.0mg/L和3.07×10-3mg/L.对含0.50 mg/L氢氯噻嗪的溶液平行测定11次,相对标准偏差(RSD)为4.4%.该方法应用于氢氯噻嗪片中氢氯噻嗪含量的测定,获得满意结果.Hydrochlorothiazide is a kind of forbidden medicines for sportsmen. It was observed that hydrochlorothiazide could greatly enhance the chemiluminescence （CL） intensity of tris-（2,2＇-bipyridyl）ruthenium（ Ⅱ ） （Ru（bipy）^2＋ 3 ）-Ce（IV） system. Based on which, a novel CL method was developed for detecting it. Under the optimum experimental conditions, the linear range and detection limit of the proposed method were 5.0 × 10^-3-2. 0 mg/L and 3.07 × 10^-3 mg/L, respectively. The relative standard deviation of determining solutions containing 0. 5 mg/L hydrochlorothiazide was 4.4% （n= 11）. The proposed CL method was applied to detect hydrochlorothiazide in hydrochlorothiazide tables with satisfactory results.

关 键 词：氢氯噻嗪 化学发光 Ru(bipy)^2+ 3 铈 

分 类 号：O657.3[理学—分析化学]