聚对二氧六环酮及其共聚物的合成与性能  

Synthesis and Quality of Poly(Dioxanone) and Copolymerization

作　　者：许韵华[1] 李蔚[1] 曲凡歧[1] 

机构地区：[1]武汉大学化学与分子科学学院

出　　处：《武汉大学学报（理学版）》2007年第2期165-169,共5页Journal of Wuhan University:Natural Science Edition

基　　金：国家自然科学基金资助项目(20572081)

摘　　要：给出了新型功能化单体5-苄氧甲基-1,4-二氧六环-2-酮(BDON)的合成方法,并将其中间体5-羟甲基-1,4-二氧六环-2-酮(HDON)的产率由文献值的35%提高到48%,同时还研究了BDON在不同催化剂Sn(Oct)2、Al(OiPr)3和Al(OiBu)3的存在下的本体开环聚合,得到分子量为19 200的聚合物,研究了聚合温度、时间、催化剂以及催化剂浓度对单体转化率和分子量的影响.通过催化氢化去除苄基保护基得到聚(5-羟甲基-1,4-二氧六环-2-酮)(PHDON),并用FTIR、1H NMR、13C NMR和GPC等方法对聚合物进行了表征.另外,研究了3种聚合物PHDON、PBDON和PDON在不同条件下的体外降解速率以及BDON和DON的共聚和聚合物的亲水性.This paper described the synthesis of a new functional dioxanone monomer, 5-benzyloxym-ethyl-1,4-dioxan-2-one （BDON）, and the yield of poly（5-hydroxy-methyl-1,4-dioxan-2-one） （HDON） was enhanced from 35G reported to 48G. We also studied on its ring-opening polymerization in bulk using Sn （Oct）2, AI（O^iPr）3 or Al（O^iBu）3 as an initiator. The polymer was obtained with a molecular weight of 19 200. The influence of reaction conditions, such as polymerization temperature, time, initiator and initiator concel^tration on the monomer conversion, and molecular weight have been investigated. The protecting benzyl group was removed subsequently by catalytic hydrogenation to give poly（5-hydroxymethyl-1,4- dioxan-2-one） （PHDON） with pendant hydroxyl groups. The polymers obtained were characterized by FTIR, ^1 H NMR, 13 C NMR and GPC. In vitro degradation rates of the three polymers PHDON, PBDON and PDON under different conditions were also investigated. Several copolymers P（BDON-co-DON）s were also synthesized.

关 键 词：5-苄氧甲基-1 4-二氧六环-2-酮 5-羟甲基-1 4-二氧六环-2-酮 开环聚合 聚(5-苄氧甲基-1 4-二氧六环-2-酮) 聚(5-羟甲基-1 4-二氧六环2-酮) 

分 类 号：Q636.2[生物学—生物物理学]