卡他莫拉菌151株耐万古霉素结果分析  

Analysis of resistance to vancomycin among 151 strains of moraxella catarrhalis

作　　者：潘韶霞[1] 刘新风[1] 刘振军[1] 程世亮 郑文[1] 

机构地区：[1]山东省交通医院,山东省济南市250031

出　　处：《中国厂矿医学》2007年第2期103-104,共2页Chinese Medicine of Factory and Mine

摘　　要：目的探讨卡他莫拉菌对万古霉素的耐药性。方法从各类痰标本中用常规鉴定法分离鉴定出151株卡他莫拉菌，采用纸片扩散法（K-B法），按照美国临床试验室标准委员会（NCCLS）临床及实验室标准协会（CLSI）2005年提出的标准对其进行药敏检测。结果卡他莫拉菌对万古霉素呈82．12％的耐药，敏感的只占16．56％；青霉素类、克林霉素呈70％以上的耐药，喹诺酮类呈40％以上耐药，三代头孢菌素类呈现80％以上敏感，大环内酯类呈60％以上敏感，氨基糖苷类呈现70％以上敏感，含酶抑制剂的舒氨新（氨苄西林加舒巴坦）、邦达（哌拉西林加他唑巴坦）、舒普深（头孢哌酮加舒巴坦）呈80％～90％以上敏感。结论卡他莫拉菌属革兰阴性球菌，对万古霉素有如此高的耐药，不单纯是因该菌产生β-内酰胺酶及超广谱β-内酰胺酶所致，其机制有待进一步探讨。Objective To investigate the resistance to vancomycln in moraxella catarrhalis（MC）. Methods The routine method was adopted to isolate and identificate 151 strains of MC. K-B method was used as drug-sensitive test ,according to the standard method produced by NCCLS/CLSI in 2005. Results The results of the experiment showed that the vancomycin resistance of MC was 82. 12%, and the sensitivity rate was 16. 56%. Penicillins and clindamycin resistance were over 70%. 0uinolones resistance was over 40%. The sensitiviy rate of cephens, macrolldes, aminogly cosides,β-lactamase inhibitors was over 80% ,60% ,70% ,80% - 90% respectively . Conclusions As Groin-negative coccus, such a high drug-resistance rate of MC to vancomycin is not only caused by β-lactamase and extended spsetrum β-lactamase. The certain mechanism need further study.

关 键 词：卡他莫拉菌 万古霉素 耐药性 

分 类 号：R378.1[医药卫生—病原生物学] R978.1[医药卫生—基础医学]