冠心病患者不对称二甲基精氨酸和同型半胱氨酸对一氧化氮合酶和一氧化氮的影响  

Influence of Asymmetric Dimethylarginine and Homocysteine on Nitric Oxide Synthase and Nitric Oxide in Patients with Coronary Heart Disease

作　　者：陈景开[1] 王霄[1] 陈满清[1] 赵秋良[1] 吴刚勇[1] 张丽[1] 张维维[1] 

机构地区：[1]解放军第101医院心内科,江苏无锡214044

出　　处：《中国微循环》2007年第2期125-127,共3页Journal of Chinese Microcirculation

摘　　要：目的探讨冠心病患者不对称二甲基精氨酸(ADMA)和同型半胱氨酸(Hcy)对一氧化氮合酶(NOS)和一氧化氮(NO)的影响。方法冠心病患者60例和健康体检者30例,测定其ADMA、Hcy、NOS和NO以及血糖、血脂等。结果冠心病组和对照组的ADMA分别为(1.30±0.58)μmol/L和(0.57±0.18)μmol/L、Hcy分别为(31.53±13.26)μmol/L和(20.98±6.39)μmol/L、NOS分别为(5.06±1.82)μ/mg蛋白和(7.03±1.37)μ/mg蛋白、NO分别为(2.56±0.95)nmol/L和(4.21±1.12)nmol/L,两组之间的差异显著(P<0.01)。经相关分析,NOS和NO分别与ADMA和Hcy呈负相关(P<0.05)。结论冠心病患者ADMA和Hcy显著增高,NOS活性降低和NO水平下降与ADMA和Hcy增高有关。Objective To observe the influence of asymmetric dimethylarginine and homocysteine on nitric oxide synthase and nitric oxide in patients with coronary heart disease. Methods The levels of ADMA, Hcy, total cholesterol, triglycefides, glucose and NO and activity of NOS were measured in serum of 60 cases with coronary heart disease and 30 healthy subjects. Results The levels of ADMA and Hcy of the patients were much higher than those of the controls, they were（ 1.30 ± 0. 58）μmol/L and （31.53 ± 13.26）μmol/L in patients and（0.57 ± 0. 18） μmol/L and（ 20.98 ± 6.39）μmol/L in controls respectively（P 〈 0. 01）. Compared with controls, the activity of NOS and levels of NO of patients were much lower, they were（5.06 ± 1.82） g/mg protein and（2.56 ± 0.95） nmol/L in the patients and（7.03 ± 1.37） μmg protein and（4.21 ± 1.12） nmol/L in the controls. In the patients either the activity of NOS or the level of NO had significant negative relationship to the level of ADMA or Hcy respectively（P 〈 0.05） . Conclusion The patients with coronary heart disease had higher levels of ADMA and Hcy and lower level of NO and activity of NOS. It is supposed that the lower level of NO is associated with inhibition of NOS by the higher ADMA and Hcy respectively.

关 键 词：冠心病 不对称二甲基精氨酸 同型半胱氨酸 一氧化氮 

分 类 号：R541.4[医药卫生—心血管疾病]