急性一氧化碳中毒患者血清细胞间黏附分子-1和超氧化物歧化酶的变化及临床意义  

Changes of intercellular adhesion molecule-1 and superoxide dismutase in the patients after acute carbon monoxide poisoning

作　　者：曹义战[1] 晋兴 仲月霞[1] 王伯良[1] 付国强[1] 何保健[1] 陆将[1] 

机构地区：[1]解放军第四军医大学唐都医院急诊科,西安710038 [2]西安高新医院检验科,710075

出　　处：《中国急救医学》2007年第4期289-291,共3页Chinese Journal of Critical Care Medicine

摘　　要：目的研究急性一氧化碳中毒(ACOP)患者血清细胞间黏附分子-1(ICAM-1)和超氧化物歧化酶(SOD)的变化及其临床意义。方法采用酶联免疫法和放射免疫法测定了84例ACOP患者血清ICAM-1和SOD水平,并与24例健康人对照比较。结果ICAM-1水平:轻度中毒者(362．40±82．80)ng/mL,中度中毒者(396．46±57．28)ng/mL,重度中毒者(624．67±50．18) ng/mL,明显高于健康对照者[(198．28±46．46)ng/mL,P＜0．05]。SOD水平:轻度中毒者(408．28±162．26)ng/mL,中度中毒者(386．64±215．63)ng/mL,重度中毒者(346．82±56．38)ng/ mL,明显低于健康对照者[(476．86±168．52)ng/mL,P＜0．05]。ICAM-1水平与病情程度呈正相关(r=0．48,P＜0．05),SOD水平与病情程度呈负相关(r=-0．54,P＜0．05)。结论ICAM-1和SOD与病情程度密切相关,ICAM-1和SOD可作为一氧化碳中毒患者病情的主要监测指标之一。Objective To study the changes of intercellular adhesion molecule - 1 （ ICAM - 1） and superoxide dismutase （SOD） in the patients after acute carbon monoxide poisoning （ACOP）. Method Enzyme -linked immunosorbent assay （ELISA） and radioimmunodetection were used to detect the plasma levels of ICAM - 1 and SOD in 84 patients after ACOP, and 24 healthy adults were selected as control group. Result The plasma levels of ICAM - 1 were （ 362.40 ± 82. 80 ） ng/mL, （ 396.46 ± 57.28 ） ng/ mL and（624.67 ± 50. 18 ） ng/mL in the mild, moderate and severe ACOP patients respectively, which were significantly higher than those in the normal control group（ 198.28 ±46.46） ng/mL, P 〈0.05. The plasma levels of SOD were （ 408.28 ± 162.26 ） ng/mL, （ 386.64 ± 215.63 ） ng/mL and （ 346. 82 ± 56. 38 ） ng/mL in the mild, moderate and severe ACOP patients respectively, which were significantly lower than those in the normal control group （ 476.86 ± 168.52 ） ng/mL, P 〈 0.05. The plasma levels of ICAM -1 in patients after ACOP was positive correlation with their toxic symptom（ r = 0. 48, P 〈 0.05 ）, but SOD was negative correlation （ r = - 0. 54, P 〈 0.05 ）. Condusion The changes of ICAM - 1 and SOD in patients after ACOP are closely related to their clinical symptom of poisoning, which potentially could be a laboratory index for ACOI patients.

关 键 词：急性一氧化碳中毒 细胞间黏附分子-1 超氧化物歧化酶 

分 类 号：R595.1[医药卫生—内科学] R446.61[医药卫生—临床医学]