硅钨酸催化合成乙酰水杨酸  

SYNTHESIS OF ACETYLSALICYLIC ACID CATALYZED BY SILICOTUNGSTIC ACID

作　　者：徐常龙[1] 柳闽生[2] 曹小华[1] 赵新萍[1] 薛蒙伟[2] 

机构地区：[1]九江学院化学化工学院,江西九江332000 [2]南京晓庄学院化学系,江苏南京210017

出　　处：《精细石油化工》2007年第2期36-38,共3页Speciality Petrochemicals

基　　金：江西省自然科学基金(0520037);南京晓庄学院科技资助课题(2005-NXY56)。

摘　　要：以水杨酸和乙酸酐为原料,硅钨酸为催化剂合成了乙酰水杨酸。考察了催化剂用量、反应物物料配比、反应时间、温度等因素对反应的影响。结果表明:硅钨酸具有催化活性高、稳定,对环境友好的特点。最佳工艺条件为:n(水杨酸):n(乙酸酐):n(硅钨酸)=1．0,2．5:0．002 4,76-80℃反应15 min,乙酰水杨酸收率达92．6％。The synthesis of acetylsalicylic acid from salicylic acid and acetic anhydride, using silicotungstic acid as catalyst, was studied. The influences of the catalyst quantities, ratios of reactants, reaction time and reaction temperature were investigated. The results showed that silicotungstic acid had high catalytic activity and good stability, and is an environmentally friendly catalyst. Under the optimal conditions, i. e. , the molar ratio of salicylic acid ： acetic anhydride： silicotungstic acid = 1.0 ： 2.5 ： 0. 002 4, reaction temperature 76- 80 ℃ and reaction time 15 min, the isolated yield can reach up to 92.6%.

关 键 词：乙酰水杨酸 硅钨酸 催化 水杨酸 乙酸酐 

分 类 号：O225[理学—运筹学与控制论]