布地奈德辅助治疗儿童肺炎支原体感染的疗效观察  

Budesonide inhaling auxiliary therapy after mycoplasma pneumoniae infection of children

作　　者：曹兰芳[1] 卢燕鸣[1] 马恒贵[1] 马敏[1] 

机构地区：[1]上海交通大学医学院附属仁济医院儿科,200001

出　　处：《国际呼吸杂志》2007年第8期567-569,共3页International Journal of Respiration

摘　　要：目的观察布地奈德（普米克令舒）吸入疗法对防治儿童肺炎支原体（mycoplasma pneumoniae，MP）感染的疗效。方法将120例MP感染患儿，在用阿奇霉素或红霉素治疗2～3周的基础上，按照辅助疗法的不同分成4组：原方案组、普米克令舒组、氯雷他定（克敏能）组和胸腺肽或转移因子注射组。用药前后检测外周静脉血嗜酸粒细胞阳离子蛋白（eosinophilic cationic protein，ECP）、嗜酸粒细胞（eosinophilic，EOS）、白介素4（interleukin-4，IL-4）和总IgE（total Immunoglobulin E，T—IgE）。结果普米克令舒吸入组与其它两组疗法的临床症状消失时间，比原方案组显著缩短，而且3个月内反复呼吸道感染次数显著减少。其中，普米克令舒吸入组疗程最短。原方案组除ECP在用药后降低外，IL-4和T—IgE均无明显变化；而原方案加普米克令舒吸人等辅助疗法三组用药后ECP、EOS、IL-4都有明显下降，差异有统计学意义，T—IgE水平基本无变化。结论在缩短疗程方面，加用小剂量激素吸入疗法是首选的辅助疗法；免疫调节剂和抗过敏药物能够促进儿童MP感染后的康复，降低复发频率，从而提高儿童MP感染的防治水平。Objective To compare the effect of budesonide（bedusonide） in prevention and cure mycoplasma of pneumonae（MP） infection. Methods At treated with azithromycin or erythromycin for 2-3 weeks, 120 MP infected cases were divided into four different groups according to different auxiliary therapy. Control group, bedusonide （pulmicort） group, carityne group, thymosin or TF （ transfer factor） injection group, then the eosinohilic cationic protein （ECP）, eosinohilic （EOS）, interleukin-4 （IL-4） and total immunoglobulin-E（T-IgE） were detected before and after using drugs administration. Results The clinical symptom disappearing period of the groups using drugs shortened significantly compared with that of the control group,and the frequency of the recurrent respiratory tract infection reduced significantly. The effect of the group inhaling bedesonide was the best. ECP, EOS, IL-4 of all groups decreased significantly except T- IgE after therapy. Conclusions So little dose glucocorticoid inhalation therapy is the best assist therapy to prevent and treat MP infection. Anti-hypersensitivity drugs and immunomodulator can improve the recovery of MP infection,thus reducing the chance of recurrent infection,and enhance the level of the preventing and treating MP infection.

关 键 词：肺炎支原体 布地奈德 儿童 

分 类 号：R72[医药卫生—儿科]