固体脂质纳米粒作为防晒剂载体的性能研究  

Characteristics of solid lipid nanoparticles as carrier system for sunscreen agent

作　　者：侯冬枝[1] 谢长生[2] 平其能[1] 

机构地区：[1]中国药科大学药剂学教研室,南京210009 [2]华中科技大学材料学院模具技术国家重点实验室,武汉430074

出　　处：《中国药科大学学报》2007年第2期177-180,共4页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.50271029)~~

摘　　要：目的:研究两类载体系统的紫外保护效果,其中一类载体为传统的O/W乳液,另一类为固体脂质纳米粒(SLN)。方法:采用激光粒度仪(LD)、UV扫描仪、差示扫描量热法(DSC)和X射线衍射(XRD)等检测手段对载体性能进行研究。结果:无论是否载药,SLN载体系统紫外吸收能力都较O/W乳液高得多,尤其是由硬脂酸和三棕榈酸甘油酯两种脂质材料制备的SLN的紫外吸收能力是乳液的两倍。DSC和XRD分析证实具有较高结晶度的脂质材料制备的SLN具有较强的紫外吸收能力。结论:决定纳米载体紫外吸收能力的是脂质材料的结晶度,而不是载体与脂质材料熔融焓相比得来的相对结晶度。Aim：Several lipid materials were employed to study in vitro UV protection effect of two different carrier systems with the same loaded amount sunscreen. One system included two types of conventional O/W emulsions;the other three kinds of solid lipid nanoparticles （ SLN ）. Methods： Laser diffractometry （ LD ）, UV-detection, thermal analysis DSC and X-ray measurements were performed. Results： It was found that the SLN carrier system with or without sunscreen incorporation showed much more higher UV absorbing capability than O/W emulsions, especially the stearic and tripalmitin SLN carriers with twice higher UV absorption. DSC and X-ray investigations indicated that SLN sample made from the higher crystalline of the lipid matrix revealed distinct improvement of UV protective property. More importantly, it was found that the crystallinity of the bulk matrix rather than the relative crystallinity of the enthalpy ratio of freeze-dried SLN to its bulk matrix was main determinant of the property of UV absorption of nano carrier. Conclusion：SLN carrier system with respect to its special characteristics should offer a bright prospect to the sunsereen field of cosmetics.

关 键 词：固体脂质纳米粒 防晒剂 紫外吸收 差示扫描量热法 

分 类 号：R944[医药卫生—药剂学]