芒果叶提取物体外抗菌作用研究  

Study on Antibacterial Action of Extracts of Leaves of Mangifera indica in Vitro

作　　者：刘雪萍[1] 蒋伟哲[1] 黄兴振[1] 黄增琼[1] 黄敏[1] 

机构地区：[1]广西医科大学第一附属医院新药研究开发中心,广西南宁530021

出　　处：《中国药业》2007年第9期12-13,共2页China Pharmaceuticals

摘　　要：目的研究芒果叶提取物的体外抗菌效果。方法采用琼脂二倍稀释法,观察芒果叶提取物对临床常见呼吸道感染菌的抑制作用。结果芒果叶提取物对6种常见的呼吸道感染菌(铜绿假单胞菌、大肠埃希菌、肺炎克雷伯杆菌、鲍氏不动杆菌、金黄色葡萄球菌和表皮葡萄球菌)有较强的体外抑制作用,其最低抑菌浓度(MIC)为0.107～0.320mg/mL;细菌接种量增加和培养基pH值降低均可使芒果叶提取物的MIC增加1～3倍。结论芒果叶提取物对6种常见呼吸道感染菌具有较强的体外抗菌作用。Objective To study on the antibacterial action of extracts of the leaves of Mangifera indica in vitro. Methods To observe the antibacterial action of extracts of the leaves of Mangifera indica on common clinical bacterials, with the two- fold agar dilution method. Results The extracts of the leaves of Mangifera indica showed the strong inhibitory effects on common clinical pathogens such as P. aeruginosa, E. coli, K. peneumoniae, Acinetobacter baumannii, S. aureus, S. epidermidis. MIC of the extracts of the leaves of Mangifera indica were between 0. 107-0.320 mg/mL. The activity of inhibition was affected by inoculative quantity and pH value of dilution, MIC was decreased when inoculative quantity was increased or the pH value of dilution was decreased. Conclusion The extracts of the leaves of Mangifera indica has strong inhibition on bacteria in vitro. The results provide a basis for clinical application of Mangiferin.

关 键 词：芒果叶提取物 琼脂二倍稀释法 体外抗菌作用 

分 类 号：R915[医药卫生—微生物与生化药学] R282.71[医药卫生—药学]