氨氯地平、培哚普利治疗高血压患者的效果和对心肾功能的影响  

The Effect of Amlodipine and Perindopril on Heart and Renal Functions in Patients with Enssential Hypertension

作　　者：姚强[1] 喻良波[1] 阮力[1] 向群[1] 

机构地区：[1]怀化医学高等专科学校附属怀化市第五人民医院心内科,湖南怀化418000

出　　处：《实用临床医学（江西）》2007年第4期15-17,共3页Practical Clinical Medicine

摘　　要：目的:探讨氨氯地平、培哚普利单独和联用治疗高血压病人的效果和对心、肾功能的影响。方法:120例高血压患者随机分成3组:A组40例,氨氯地平5 mg,口服,1次/d;B组40例,培哚普利4 mg,口服,1次/d;C组40例,氨氯地平5 mg+培哚普利4 mg,口服,1次/d。均治疗24周。治疗前后观察血压、脉压、心率、心功能(NY-HA)、6 min步行试验2、4 h尿白蛋白、尿蛋白、血尿素氮、血肌酐和药物不良反应。结果:治疗后24周,3组血压、心率均明显下降,C组收缩压下降>A、B组(P<0.01),脉压减小优于A、B组(P<0.01)。6 min步行试验、NY-HA均明显改善,24 h尿白蛋白、尿蛋白、尿素氮、肌酐排泄下降,C组均比A、B组好,无不良反应。结论:氨氯地平和培哚普利联用,是加强降血压、缩小脉压、改善心肾功能的安全有效方法。Objective：To examine the effects of Amlodipine （Amlo） and perindopril（perl） used individually or in combination on heart and renal functions in patients with essential hypertension （EH）. Methods： One hundred and twenty cases with EH were divided randomly into three groups： group A： Amlo 5mg QD,n=40; group B： peri 4mg QD,n=40; group C：Amlo 5mgQD ＋peri4mg,n=40,treatment lasted for 24 weeks, parameter of Blood pressurel（BP）, pulse pres- sure （pp） heart Rate（HR）,6-minute working test（6-mwt） NYHA,24 h urinary albumin urine protein,BUN,Cr were measured before and after treatment. Results：After treatment BP and HR were significantly less than those before treatment in all the three groups. But SBP in group C were decreased than groups A and B, pp were decreased significantly than A,B group, 6-mwt, NYHA were improved, urinary albumin proteinuria, BUN, Cr excretion were signicanfitly decreased after treatment of three groups. The results in group C were better than groups A and B. Conclusion： The data suggest that one of the beneficial effects and safes on Amlodipine conbined with perindopril treatment has achieved. They and renal function. have effect on BP, PP, HR and improved the heart

关 键 词：高血压 脉压 氨氯地平 培哚普利 心功能 肾功能 

分 类 号：R544.11[医药卫生—心血管疾病]