青藤碱治疗类风湿关节炎100例临床研究  

The Clinical Study on Sinomenine for 100 Patients with Rheumatoid Arthritis

作　　者：黄国栋[1] 李家邦[1] 黄媛华[2] 黄道富[2] 唐丽君[3] 张曙[3] 李倩[4] 

机构地区：[1]中南大学湘雅医院中西医结合研究所,长沙410008 [2]湖南中医学院附属衡阳医院,衡阳421001 [3]湖南省人民医院,长沙410002 [4]湖南中医学院附属第一医院,长沙410007

出　　处：《中国中医急症》2007年第4期416-417,421,共3页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的观察青藤碱治疗类风湿关节炎(RA)的临床疗效。方法将169例RA患者随机分为治疗组(100例)与对照组(96例),分别采取青藤碱和雷公藤多苷片治疗,并比较治疗前后临床症状、体征的改善情况及实验室指标(ESR、RF、CRP、IgG、IgA、IgM、补体C3)的变化。结果治疗组总有效率为93.00%,对照组总有效率为67.71%;两组治疗后临床症状、体征改善,治疗组较对照组更显著;治疗组治疗后前述七项实验室指标与治疗前比较均有改善,而对照组七项指标中ESR、RF、CRP、IgA改善,且治疗组ESR、RF、CRP、IgG、IgA治疗后改善程度明显优于对照组。结论青藤碱对RA有较好的疗效,疗效优于雷公藤多苷。Objective： To observe the effect of Sinomenine （SN） in treating rheumatoid arthritis （RA）. Methods： Patients were randomly divided into two groups, 100 in the treatment group（received SN） and 96 in the control group（received tripterygium glycosides tablet）. The changes of chinical symptoms and signs as well as laboratory critera, including ESR, RF, CRP, IgG, IgA, IgM, and C3 of the patients,were observed. Results： The total effective rate of the treatment group （93.00%） was obviously higher than that of the control group （67.71%）. Clinical symptoms and signs were improved significantly after treatments in both groups, while the improvement of the treatment group was more obviously than that of the control group. Of the patients in the treatment group, the former, 7 items of laboratory criteria were improved significantly after the treatment, while in the controlling group, significant changes were only shown in ERS, RF, CRP and IgM, and the ERS, RF, RP, IgG and IgA of patinets in the treatment group after the treatment were all better than in the control group respectively. Conclusion： SN has better therapeutic effect for RA than tripterygium glcycosides tablet.

关 键 词：类风湿关节炎 青藤碱 

分 类 号：R593.22[医药卫生—内科学]