细菌多重耐药外排泵抑制剂研究进展  

Advances in the research on bacterial multi-drug resistance efflux pump inhibitors

作　　者：刘忆霜[1] 肖春玲[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所,北京100050

出　　处：《中国抗生素杂志》2007年第4期211-216,244,共7页Chinese Journal of Antibiotics

摘　　要：细菌耐药性,尤其是多重耐药性(multi-drug resistance,MDR)已经成为非常严重的医疗问题,而多种类型细菌外排泵(efflux pumps)的存在是细菌多重耐药的重要机制,因此寻找有应用前景的外排泵抑制剂(efflux pump inhibitors,EPI)是十分必要且迫切的。目前已经发现外排泵抑制剂的作用机制分为:(1)干扰外排泵组装;(2)阻断外排泵能量来源;(3)阻碍底物通过外排通道;(4)机制未知。本文按照作用机制对已经发现的细菌多重耐药外排泵抑制剂的特点进行分述。Bacterial resistance to antibiotics, especially the multi-drug resistance （MDR） has become a serious problem of healthcare. The existence of various kinds of efflux pumps is one of the important mechanisms of bacterial resistance. It is exigent to discover the efflux pump inhibitors which could be used in clinic. So far, various kinds of efflux pump inhibitors have been discovered. Their mechanisms of action are （1） interfering the assembling of efflux pumps, （2） blocking the energy supply of efflux pumps, （3） hindering the transit of substrates through the efflux tunnel and （4） unknown mechanism. According to the mechanisms of action, the characters of bacterial multi-drug resistance efflux pump inhibitors discovered by far were summarized in this review.

关 键 词：细菌多重耐药性 外排泵 抑制剂 

分 类 号：R378[医药卫生—病原生物学]