老年原发性高血压患者阿司匹林抵抗的相关因素探讨  

Correlative factors of aspirin resistance in elderly hypertension patients

作　　者：饶一武[1] 刘鹏[1] 李国玲[2] 余正堂[1] 周丽芹[1] 刘青云[1] 周晓莉[1] 

机构地区：[1]郧阳医学院附属医院东风总医院老年科,湖北省十堰市442000 [2]郧阳医学院附属医院东风总医院检验科,湖北省十堰市442000

出　　处：《中国综合临床》2007年第5期395-397,共3页Clinical Medicine of China

摘　　要：目的探讨老年原发性高血压患者阿司匹林抵抗的相关因素。方法记录80例原发性高血压患者病史、体质指数等临床资料，检测患者血小板聚集率、血脂、C反应蛋白（CRP）水平及24h平均脉压（24hPP），多元逐步回归方法分析各因素与血小板聚集率的相关性。结果女性半阿司匹林抵抗多见（x^2=6．327，P=0．015），而与阿司匹林抵抗无相关性。阿司匹林抵抗与低密度脂蛋白胆固醇（LDL．C）（t=3．348，P=0．002）、CRP浓度呈显著相关（t值分别为3．348、2．646，P值分别为0．002、0．012），与24h平均脉压（PP）呈良好相关（P=0．024），而与其他因素无关。结论半阿司匹林抵抗现象可能与性别有关，而阿司匹林抵抗现象可能与LDL．C、CRP、24hPP等因素有关，在这些状态下，应警惕阿司匹林抵抗的发生，必要时可增加剂量或用其他药物替代。Objective To investigate the relative factors of aspirin resistance in the elderly hypertension patients （ EH ）. Methods The history and mass index of 80 patients with hypertension was analyzed and the platelet aggregation index, blood lipid, C-reactive protein （CRP） ,24 h pulse pressure （PP） were detected. Results The half aspirin resistance mostly happened in female （ X^2 = 6. 327, P = 0. 015 ） , and no relationship with aspirin resistance was shown. The phenomenon of aspirin resistance was highly related with 24 h PP（ P = 0. 024 ） and aspirin resistance significantly related with LDL-C concentration （ t = 3. 348, P = 0.002 ） , CRP （ t = 2.646, P = 0.012 ） , and not related with other factors. Condnsion Half aspirin resistance might be correlated with female. Aspirin resistance is more likely correlated with biochemical as well as clinical conditions such as LDL-C, CRP and 24 h PP. Some precautions against these conditions should be taken into consideration;the increased dosage, or the replacement therapy may be prescribed if necessary.

关 键 词：原发性高血压 阿司匹林 脂类 C反应蛋白 脉压 

分 类 号：R544[医药卫生—心血管疾病]