胶原涂层记忆合金人工气管的实验研究  

Tracheal Reconstruction with Memory Alloy Prosthesis Coated with Collagen

作　　者：林海平[1] 曹子昂[1] 顾旭东[1] 潘文标[1] 吴学军[1] 张谷兰[1] 

机构地区：[1]上海交通大学医学院附属仁济医院心胸外科,上海200127

出　　处：《中国医疗器械杂志》2007年第2期88-90,共3页Chinese Journal of Medical Instrumentation

摘　　要：目的:构建胶原涂层记忆合金人工气管,通过动物实验观察其气管重建的初步效果。方法:用记忆合金丝编织成圆柱形网管作为基本支架,网管内壁镀聚氨酯膜封闭网孔,在管腔内外壁涂覆胶原海绵涂层。以此型人工气管对8只犬行颈段气管的置换重建,术后通过X光摄片、气管镜和动物处死后组织标本的病理检查来评价实验效果。结果:1只实验犬于术后10天因假体脱位死亡,另一只犬术后45天因出现吻合口狭窄而处死,其余6只犬已存活90天以上,最长150天。人工气管在位佳,管腔通畅无狭窄,吻合口有气管上皮覆盖。结论:胶原涂层记忆合金人工气管可用于气管的重建,但远期效果还需进一步观察。Objective To investigate the feasibility of tracheal reconstruction with a prosthesis made of memory alloy coated with collagen sponge in mongrel dogs. Method The basic skeleton of the prosthesis was knitted with Ni-Ti memory alloy wires. The tubular mesh was sealed with polyurethane membrane and then inner and external walls of the lumen were coated with collagen sponge. Cervical trachea segmental reconstruction was performed in 8 mongrel dogs with these prostheses. The efficacy of the implanted prostheses were periodically evaluated after operation using x-ray, tracheoscope and specimen microscope examinations. Results One dog died of prosthesis dislocation 10 days after operation, another was killed 45 days later because of anastomotic stenosis. 6 dogs survived more than 90 days and the longest one lived for 150 days. Its implanted prosthesis was completely incorporated with the recipient tissue,where re-epithelialization occulted on anastomotic sites. The tracheal lumen was patent. Conclusion This memory alloy tracheal prosthesis has been proved useful for reconstruction of large, circumferential tracheal defects, although its long-term safety and efficiency need to be confirmed.

关 键 词：人工气管 气管重建 记忆合金 动物模型 

分 类 号：R318.11[医药卫生—生物医学工程]