生物芯片图像分析的研究进展  

Progress in a Research on Biochip Image Analysis

作　　者：刘国传[1] 伯晓晨[1] 王升启[1] 陆琳[2] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850 [2]中华人民共和国北京出入境检验检疫局,北京100026

出　　处：《中国医疗器械杂志》2007年第2期108-111,共4页Chinese Journal of Medical Instrumentation

基　　金："十五"国家科技攻关计划项目"重大人兽共患病诊断平台"(2004BA519A46);国家自然科学基金重点项目(39889001)资助。

摘　　要：生物芯片图像分析是生物芯片中至关重要的一个环节,图像分析效果的好坏直接影响到检测结果的精度和准确性,进而影响生物芯片的推广与使用。结合生物芯片图象的特点,对生物芯片图象去噪和样点自动识别作一综述。Microarray imaging is consideredas an important tool for large scale analysis of gene expression. The accuracy of the gene expression depends on the experiment itself and further image processing. It＇s well known that the image analysis introduced during the experiment will greatly affect the accuracy of the gene expression. Microarray image analysis plays a potentially-arge impact on the gene detecting subsequent analysis （image segmentation,spot intensity and spot intensity extraction）.ln this paper, based on the characters of microarray images, the methods of microarray images＇ denoising and automatic-identification of the spot are reviewed.

关 键 词：生物芯片 图象去噪 样点自动识别 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术]