布托啡诺与吗啡用于开胸术后患者自控镇痛的比较  

Efficacy of patient-controlled analgesia with morphine versus butorphanol in patients after thoracotomy

作　　者：谢致[1] 周守静[1] 俞莹芳[1] 

机构地区：[1]复旦大学附属华山医院麻醉科,上海200040

出　　处：《复旦学报（医学版）》2007年第2期299-301,共3页Fudan University Journal of Medical Sciences

摘　　要：目的比较布托啡诺与吗啡用于开胸术后患者自控镇痛的疗效及不良反应。方法40例择期行开胸手术的病人,术后随机分为布托啡诺组(B组)和吗啡组(M组),分别接受静脉自控镇痛(PCA)治疗。镇痛效果评价采用视觉模拟评分(VAS)。结果两组患者术后各时段的VAS评分无统计学差异,而不良反应的发生率B组明显少于M组。结论布托啡诺用于开胸术后PCA可取得满意的镇痛效果,且不良反应低于吗啡。Purpose To compare the efficacy and safety of butorphanol versus morphine for patients controlled analgesia （PCA） in patients after thoracotomy. Methods A prospective, randomized, double-blind clinical study recruited 40 patients undergoing elective thoracotomy, who were randomly i v administered with either morphine （0.5mg/mL,n = 20） or butorphanol （0. 1mg/mL, n = 20） after surgery. The efficacy of pain relief was assessed using a visual analogue scale （VAS）. Results No statistical difference in the analgesic effect was found between the two groups. Patients of butorphanol group had fewer incidence of adverse events than those of morphine group. Conclusions Butorphanol offers an alternative to morphine for patient-controlled analgesia in patients after thoracotomy.

关 键 词：术后镇痛 布托啡诺 吗啡 开胸手术 

分 类 号：R614[医药卫生—麻醉学]