蒽环类药物对肿瘤患者左心功能影响的组织多普勒评价  

Study of assessment of left ventricular function in malignant patients treated with anthracycline using tissue Doppler imaging

作　　者：张小花[1] 姜志荣[1] 李大海[2] 褚强[1] 

机构地区：[1]青岛大学医学院附属医院心脏超声科,266003 [2]河北大学附属医院超声科

出　　处：《临床超声医学杂志》2007年第3期151-153,共3页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨组织多普勒技术(TDI)在评价蒽环类药物(ATC)对肿瘤患者左心功能早期损害的临床应用价值。方法测定并比较26例肿瘤患者ATC化疗前和化疗后6个月的常规超声心动图参数及TDI参数。结果TDI显示ATC化疗后二尖瓣环的收缩期运动速度峰值(Sm)及舒张早期运动速度峰值(Em)较化疗前明显降低(P<0.05),心房收缩期运动速度峰值(Am)较化疗前明显升高(P<0.01),Em/Am较化疗前明显降低(P<0.01),但舒张早期左室充盈峰速度(E)、心房收缩期左室充盈峰速度(A)、E/A、E峰减速时间(DT)、左室等容舒张时间(IVRT)及射血分数(EF)、短轴缩短率(FS)等常规心功能指标化疗前后差异无显著性(P>0.05)。结论TDI技术能更早、更敏感地评价ATC对肿瘤患者左室功能损害。Objective To explore the clinical value of tissue Doppler imaging（TDI）in assessing left vennticular function damage in malignant patients receiving cardiotoxic anthracycline chemtherapy.Metheds Twenty- six patients were examined by echocardiography and tissue Doppler imaging before anthracycline chemotherapy and six months after anthracycline chemotherapy. Results Parameters of TDI showed： after anthracycline chemotherapy, the peak motion velocity during systolic period and early diastolic period of mitral annulus decreased（ P 〈 0.05） ,while the peak velocity during atria contraction period increased（ P 〈 0.01）,the ratio of Em/Am increased（ P 〈0.01）.Parameters acquired from common echocardiography showed： left ventricular diastolic function and short-axis systolic function after chemotherapy had no statistic significance compared with those data acquired before chemotherapy. Compared with common echocardiography, TDI is more sensitive in detecting abnormalities of left ventricular function.

关 键 词：超声心动描记术 心室功能 左 组织多普勒 蒽环类药物 

分 类 号：R979.1[医药卫生—药品]