血清胱抑素C在妊娠期高血压早期肾损害中的意义  

Serum Cystatin C As an Early Renopathy Markers for Pregnancy-induced Hypertension

作　　者：陈静[1] 程祖建[1] 翁义锐[1] 林寿榕[1] 

机构地区：[1]福建医科大学附属第一医院检验科,福建福州350005

出　　处：《中华高血压杂志》2007年第3期238-240,共3页Chinese Journal of Hypertension

摘　　要：目的评价血清胱抑素C(CysC)在妊娠期高血压(GH)早期肾损害中的意义。方法收集GH患者40例、正常妊娠妇女70例(其中早中期妊娠35例,晚期妊娠35例)和30例正常对照者血清,以颗粒增强散射比浊法测定CysC、β2微球蛋白(β2-M),以生化分析法测定尿素氮(BUN)、血肌酐(SCr)、尿酸(UA)含量,并加以比较。结果正常血压晚期妊娠组(1.22±0.19)mg/L与GH组(1.93±0.48)mg/L的CysC水平均明显高于健康体检组[(0.78±0.22)mg/L,P<0.05和P<0.01];同时,GH组CysC水平高于正常血压晚期妊娠组(P<0.05);正常早中期妊娠组CysC水平与正常对照组无明显差异;GH组CysC水平与UA呈正相关(r=0.46,P<0.05)。结论血清CysC是评价妊娠期高血压早期肾功能损害的一项敏感和可靠的指标。Objective To evaluate cystatin C（CysC）in early impairment of renal function in patients of gestational hypertension（GH）.Methods Forty patients of GH,70 normotensive pregnant women（35 of early pregnany and 35 of late pregnancy）and 30 normotensive healthy women were enrolled.CysC and β2-M were measured by particle enhanced nephelometric assay,SCr,BUN and UA were measured by biochemistry analysis.Results The level of CysC in normotensive late pregnancy subjects（1.22±0.19 mg/L）and GH patients（1.93±0.48 mg/L）were higher than that in normal healthy women（0. 78±0.22 mg/L, P〈0. 05 and P〈0. 01）; the level of CysC in GH women was higher than that in normotensive late pregnancy group （P〈0.05） ; CysC was positively related with UA in GH women （r=0.46, P〈0.05）. Conclusion CysC is a sensitive and reliable indicator for the diagnosis of early impairment of renal function of gestational hypertension.

关 键 词：妊娠期高血压 胱抑素C 肾功能损害 

分 类 号：R714.246[医药卫生—妇产科学]